{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:07:24Z","timestamp":1780301244362,"version":"3.54.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Atopic comorbidities are common in chronic spontaneous urticaria (CSU), yet their impact on clinical presentation and omalizumab response remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare clinical profiles and omalizumab treatment outcomes in CSU patients with atopic dermatitis (AD) and other atopic comorbidities (OACs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center retrospective study included 381 CSU patients treated with \u22653 doses of omalizumab (300 mg\/4 weeks) and followed \u22656 months (January 2023\u2013March 2025). Based on the presence or history of atopic comorbidities, patients were stratified into 3 groups: CSU with AD (CSU-AD, n = 76), CSU with OACs (CSU-OACs, n = 93), and CSU with no atopic comorbidities (CSU-NA, n = 212). Clinical features, treatment response (efficacy, speed, and adverse events), and\u2014among 12-month completers\u2014dose reduction\/discontinuation and drug survival rates were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of all enrolled patients, 44.4% had comorbid allergic diseases. CSU-OACs patients had earlier onset (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033) and higher angioedema prevalence (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.042); CSU-AD showed higher baseline UAS7 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031). Overall omalizumab response rates did not differ significantly among the 3 groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.115), but a significantly higher portion of faster-response speed was observed in CSU-OAC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019). Adverse events were significantly higher in CSU-OACs (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004), especially injection-site reactions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033) and systemic effects (eg, headache and fatigue;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025). Drug survival was significantly higher in the CSU-OAC vs. CSU-NA group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CSU-AD differs only in higher baseline activity, otherwise resembling CSU-NA in treatment response and drug survival. CSU-OACs exhibit not only distinct features such as earlier onset, higher angioedema risk, faster response, and higher drug survival but also more adverse events, indicating that CSU-OAC requires individualized management. Larger multicenter studies are needed to further define the impact of AD and OACs in CSU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261455284","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:33:55Z","timestamp":1780032835000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Spontaneous Urticaria Combined Atopic Dermatitis\/Other Atopic Comorbidities: Clinical Characteristics, Therapeutic Response to Omalizumab, and Drug Survival"],"prefix":"10.1177","author":[{"given":"Ruiguo","family":"Li","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjie","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Huang","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifei","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikun","family":"Mu","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Song","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, 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