{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:29:21Z","timestamp":1787495361465,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acrylate allergy is rising, with many patients showing patch test positivity to multiple acrylates. Understanding acrylate sensitivity can guide avoidance and optimize screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To quantify acrylate patch test positivity, define subgroups using hierarchical clustering, and algorithmically optimize acrylate patch testing series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective review of 27 acrylate allergens patch tested at 3 Mayo Clinic sites (Arizona, Florida, Minnesota) from 1997 to 2024; 14 had \u22651% positivity. Pairwise copositivity rates were background-corrected and analyzed using hierarchical clustering, followed by computational optimization for patch test screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 17,148 patients, 90,818 tests yielded 1,557 positives (1.71%). Most frequent positive reactions were 2-hydroxyethyl acrylate 0.1% (HEA, 5.4%), 2-hydroxypropyl methacrylate 2% (HPMA, 5.0%), and 2-hydroxyethyl methacrylate 2% (HEMA, 4.6%). Clustering revealed 2 general subgroups, with ethyl cyanoacrylate 10% (ECA) showing minimal copositivity to other acrylates. Optimization analysis for screening showed that one allergen (HEMA) captured 49.4% of sensitized patients; 2 (HEMA + ECA) captured 72.2%. Four allergens, including HEMA, ECA, HEA, and diethylene glycol diacrylate 0.1% (DEGDA), captured &gt;90%, and a 7-allergen series captured 100%, with no higher yield from additional acrylates in standard screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Acrylate allergy is heterogeneous, comprising 2 subgroups, with cyanoacrylates co-reacting separately. Algorithm-guided series refinement improves diagnostic efficiency by prioritizing high-yield allergens for screening while minimizing unnecessary testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261479501","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:06:11Z","timestamp":1787375171000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acrylate Patch Testing for Allergic Contact Dermatitis Over 28 Years: Hierarchical Clustering for Subgroup Analysis and Computational Optimization for Patch Test Selection"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0869-8527","authenticated-orcid":false,"given":"JennaKay","family":"Colquitt","sequence":"first","affiliation":[{"name":"From the \rMayo Clinic Alix School of Medicine, Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Yiannias","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.P.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly J.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yul W.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v104.41079"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/der.0000000000000549"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12266"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31823d1b81"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12942"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2011.10093"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12684"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.12788\/cutis.0909"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12348"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0063"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.3774"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.2352"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0442"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.06.061"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29017.jdk"},{"key":"e_1_3_1_17_1","unstructured":"16.U.S. Food and Drug Administration. T.R.U.E. TEST (Thin-layer Rapid Use Epicutaneous patch test). FDA website; 2019. Available from: https:\/\/www.fda.gov\/vaccines-blood-biologics\/allergenics\/true-test [Last accessed: January25 2026]."},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000621"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12647"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13278"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13216"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12817"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000889"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14430"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02144.x"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00405.x"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000301"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/1046-199X(95)90104-3"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14838"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261479501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568261479501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261479501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T13:46:23Z","timestamp":1787492783000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568261479501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":28,"alternative-id":["10.1177\/17103568261479501"],"URL":"https:\/\/doi.org\/10.1177\/17103568261479501","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"article-number":"17103568261479501"}}