{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:57:30Z","timestamp":1790521050177,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lebrikizumab has recently been approved for moderate-to-severe atopic dermatitis (AD), but real-world evidence across different patient subgroups remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the real-world effectiveness and safety of lebrikizumab in adults with moderate-to-severe AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter observational study included adults with moderate-to-severe AD treated with lebrikizumab for at least 16 weeks at eight Italian university hospitals between March and December 2025. Outcomes were assessed at baseline and weeks 16 and 24. The primary endpoint was achievement of at least a 75% improvement in the Eczema Area and Severity Index (EASI75) at week 16. Secondary outcomes included EASI90, EASI100, pruritus and sleep Numeric Rating Scale scores, Dermatology Life Quality Index, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ninety-one patients were included; 56% were male, mean age was 37.9 years, and mean baseline EASI was 21.2. At week 16, EASI75, EASI90, and EASI100 were achieved by 49.5%, 20.9%, and 9.9% of patients, respectively. At week 24, response rates increased to 58.6%, 32.8%, and 25.9%, respectively. Clinically meaningful improvements were also observed in pruritus, sleep disturbance, and quality of life. Biologic- and JAK inhibitor\u2013naive patients showed numerically higher response rates than previously treated patients, whereas no significant differences were observed according to age, sex, atopic comorbidities, or disease duration. Treatment-emergent adverse events occurred in 23.1% of patients and were mainly mild to moderate. Conjunctivitis was the most frequent adverse event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lebrikizumab demonstrated favorable real-world effectiveness and safety in adults with moderate-to-severe AD after 16 weeks of treatment, with clinical and patient-reported improvements maintained through week 24.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261489007","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:11:31Z","timestamp":1790215891000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lebrikizumab in Atopic Dermatitis: Associations of Patient Characteristics and Treatment History with Clinical Outcomes"],"prefix":"10.1177","author":[{"given":"Niccol\u00f2","family":"Gori","sequence":"first","affiliation":[{"name":"From the *Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-5175","authenticated-orcid":false,"given":"Marco","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, Rome, Italy"},{"name":"Dermatology Unit, Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ippoliti","sequence":"additional","affiliation":[{"name":"From the *Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"From the *Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Dermatology Section, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Capo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science, Dermatology Unit, University G. D\u2019Annunzio, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Chello","sequence":"additional","affiliation":[{"name":"Department of Medical and Cardiovascular Sciences, Dermatology Clinic, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mariano","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute-IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Martina","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Ospedale Carlo Urbani, Jesi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Moretta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Unit, Istituto Dermopatico dell\u2019Immacolata\u2014Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mortato","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Maria","family":"Magnanimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019\u2009Aquila, L\u2019\u2009Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Skroza","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, ASL Latina, Sapienza University of Rome, Latina, Terracina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Amerio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science, Dermatology Unit, University G. D\u2019Annunzio, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campanati","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Del","family":"Duca","sequence":"additional","affiliation":[{"name":"Department of Medical and Cardiovascular Sciences, Dermatology Clinic, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"De Pit\u00e0","sequence":"additional","affiliation":[{"name":"Department of Dermatology Unit, Istituto Dermopatico dell\u2019Immacolata\u2014Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019\u2009Aquila, L\u2019\u2009Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Fargnoli","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute-IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Stingeni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Dermatology Section, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersilia","family":"Tolino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. 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