{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:54:47Z","timestamp":1791046487242,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Allergic contact dermatitis (ACD), can involve any area of the body. However, the anogenital region remains under-studied and diagnostically challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association between age and patch test results in women presenting with symptoms suggestive of anogenital ACD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 10-year retrospective cohort study of female patients with anogenital ACD symptoms who underwent patch testing at a tertiary medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 150 women were included and divided into two age groups: younger (&lt;45 years,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 86) and older (\u226545 years,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 64). Relevant positive reactions were observed in 60% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 90) of cases. Older women had more frequent reactions to methyldibromoglutaronitrile (MDBGN) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.043), hydroperoxides of limonene (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.036) and higher positivity to the medicament series (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.039). Sensitivity to Fragrance Mix I was higher among older women with isolated anogenital symptoms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014). Although the number of tested series was similar, older women had more positive series per patient (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this exploratory, hypothesis-generating study, age-related differences in allergen sensitization emerged on patch testing. Selected fragrances, preservatives, and medicament-related allergens were more frequent among women aged \u226545 years, supporting age as an important consideration in the diagnosis and management of women with suspected anogenital ACD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261491058","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:39:15Z","timestamp":1790840355000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-Related Patterns in Anogenital Allergic Contact Dermatitis: A Retrospective Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-8392","authenticated-orcid":false,"given":"Sarit","family":"Gilboa","sequence":"first","affiliation":[{"name":"From the *Department of Dermatology, Sheba Medical Center"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orian","family":"Koren","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Lavy","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Sheba Medical Center"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Galili","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Sheba Medical Center"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lyakhovitsky","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Sheba Medical Center"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Baum","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Sheba Medical Center"},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"4","key":"e_1_3_1_2_1","first-page":"713","article-title":"Irritant and allergic contact dermatitis\u2014skin lesion characteristics","volume":"57","author":"Novak-Bili\u0107 G","year":"2018","unstructured":"1.Novak-Bili\u0107 G, , Vu\u010di\u0107 M, , Japund\u017ei\u0107 I, et al. 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