{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:40:25Z","timestamp":1792345225771,"version":"4.4.0"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Head-and-neck (H&amp;N) Eczema Area and Severity Index (EASI) sub-scores are increasingly reported, but their clinical interpretation relative to the validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Define H&amp;N EASI severity strata anchored to vIGA-AD and evaluate convergent validity and interrater reliability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-two dermatologists evaluated photographs of 21 patients with H&amp;N AD using the H&amp;N EASI and vIGA-AD. H&amp;N EASI severity strata were derived based on the empirical distribution within vIGA-AD. Kendall\u2019s tau (\u03c4) and Spearman\u2019s correlation coefficient (SCC) assessed convergent validity, and intraclass correlation coefficients (ICC) evaluated interrater reliability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      H&amp;N EASI scores aligned with vIGA-AD (0, \u201cClear\u201d; 0.1\u20130.6, \u201cAlmost clear\u201d; 0.7\u20131.7, \u201cMild\u201d; 1.8\u20133.0, \u201cModerate\u201d; and 3.1\u20134.8, \u201cSevere\u201d), showing almost perfect agreement (weighted Cohen\u2019s \u03ba = 0.83 [95% CI, 0.80\u20130.86],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). H&amp;N EASI and vIGA-AD scores were strongly correlated (\u03c4 = 0.74 [95% CI, 0.71\u20130.77]; SCC = 0.86 [95% CI, 0.83\u20130.88], both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Interrater reliability was moderate for H&amp;N EASI (0.73 [95% CI, 0.60\u20130.85]) and vIGA-AD (0.61 [95% CI, 0.46\u20130.77]) (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>H&amp;N EASI severity strata provide a reliable and clinically meaningful assessment of H&amp;N AD, aligning with facial vIGA-AD and enabling evaluation beyond global assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261496163","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:19:51Z","timestamp":1792203591000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of Head and Neck EASI Severity Strata Against vIGA-AD in Atopic Dermatitis"],"prefix":"10.1177","author":[{"given":"Amalie Thorsti M\u00f8ller","family":"R\u00f8nnstad","sequence":"first","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki M. F.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"H\u00e6rskjold","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Baastrup","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia-Louise","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Elisabeth","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Birgitte","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Hudl\u00e6gerne i Charlottenlund, Charlottenlund, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne G.","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Hudklinikken Panoptikon, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Strauss","sequence":"additional","affiliation":[{"name":"Hudklinikken Panoptikon, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise W.","family":"Idorn","sequence":"additional","affiliation":[{"name":"Hudklinikken Panoptikon, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Hald","sequence":"additional","affiliation":[{"name":"Hudklinikken i R\u00f8dovre, R\u00f8dovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Hudklinikken i R\u00f8dovre, R\u00f8dovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Sk\u00f8t","family":"Cvetkovski","sequence":"additional","affiliation":[{"name":"Hudklinikken I Det Gamle Apotek, H\u00f8rsholm, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Ammitzb\u00f8ll","sequence":"additional","affiliation":[{"name":"Hareskov Hudklinik, V\u00e6rl\u00f8se, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"M\u00f8lenberg","sequence":"additional","affiliation":[{"name":"Hudklinikken i R\u00f8dovre, R\u00f8dovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Themstrup","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Deleuran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Copenhagen University Hospital\u2014Herlev and Gentofte, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Hudklinikken i R\u00f8dovre, R\u00f8dovre, Denmark"},{"name":"Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina S.","family":"Ibler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, 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