{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:33:31Z","timestamp":1792949611837,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) in the elderly is increasing worldwide and presents therapeutic challenges due to age-related comorbidities that often contraindicate systemic therapies. Although oral Janus kinase (JAK) inhibitors show efficacy in moderate-to-severe AD, older adult patients are underrepresented in clinical trials, and regulators recommend caution in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We conducted a multicenter, retrospective, observational study at 15 Italian university hospitals, including patients with moderate-to-severe AD aged \u226560 years treated with upadacitinib 15 or 30 mg once daily, to evaluate the real-world effectiveness and safety of this selective JAK1 inhibitor at weeks 16, 32, 52, and 104.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-two patients were included (mean age 65.9 \u00b1 6.4 years); 48\/72 (66.7%) of patients showed a classical flexural phenotype; 34\/72 (47.2%) presented with head-and-neck involvement. Upadacitinib led to marked and sustained improvement in both clinician-and-patient-reported outcomes, with mean Eczema Area and Severity Index decreasing from 23.9 \u00b1 9.2 at baseline to 1.5 \u00b1 3.0 at week 52 and 0.9 \u00b1 2.5 at week 104. Mean itch-Numeric Rating Scales (NRS) decreased from 8.2 \u00b1 2.0 at baseline to 1.0 \u00b1 1.9 at week 52 and 1.0 \u00b1 2.4 at week 104, with concomitant amelioration in sleep-NRS (6.5 \u00b1 3.1 to 0.5 \u00b1 1.6 and 0.3 \u00b1 1.3) and Dermatology Life Quality Index (16.8 \u00b1 6.9 to 1.6 \u00b1 4.2 and 1.0 \u00b1 3.2). Adverse events occurred in 37\/72 (51,4%) patients and included dyslipidemia in 22\/72 (30.6%) patients, creatine phosphokinase elevation in 15\/72 (20.8%), and blood count abnormalities in 13\/72 (18.1%); they were mostly mild and manageable. Overall, 16\/72 patients (22.2%) discontinued treatment, including 11\/72 (15.3%) due to AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our multicenter real-world cohort of patients aged \u226560 years, upadacitinib demonstrated rapid, sustained efficacy and an overall favorable safety profile through 104 weeks, supporting its long-term use in clinical practice with appropriate monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261499632","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:42:53Z","timestamp":1792719773000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Upadacitinib for the Management of Atopic Dermatitis in Patients Aged \u226560 Years: A Long-Term Multicenter Real-World Study"],"prefix":"10.1177","author":[{"given":"Elena","family":"Ippoliti","sequence":"first","affiliation":[{"name":"From the *Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Gori","sequence":"additional","affiliation":[{"name":"From the *Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Coscarella","sequence":"additional","affiliation":[{"name":"From the *Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Mariel","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-7310","authenticated-orcid":false,"given":"Francesca","family":"Barei","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campanati","sequence":"additional","affiliation":[{"name":"Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Rossi","sequence":"additional","affiliation":[{"name":"Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"},{"name":"UOSD General and Oncological Dermatology, Ospedale San Salvatore, L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"De Berardinis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine and Regeneration and Ionian Area, Unit of Dermatology, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Tirone","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine and Regeneration and Ionian Area, Unit of Dermatology, University of Bari Aldo Moro, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-5175","authenticated-orcid":false,"given":"Marco","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata,\u201d Italy"},{"name":"Dermatology Unit, Azienda Ospedaliera Universitaria \u201cPoliclinico Tor Vergata,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mortato","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata,\u201d Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Antiga","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Milanesi","sequence":"additional","affiliation":[{"name":"Allergological and Occupational Dermatology Unit, Department of\u2009Health Sciences, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Maurelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"di Vico","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Narcisi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bianco","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pezzolo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, San Bortolo Hospital, Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Armando Luyo","family":"Saboya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, San Bortolo Hospital, Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Dermatology Clinic, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ortoncelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Dermatology Clinic, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"},{"name":"Dermatology Unit, ASST Spedali Civili di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bighetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"},{"name":"Dermatology Unit, ASST Spedali Civili di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Russo","sequence":"additional","affiliation":[{"name":"Dermatological Department, Istituto Dermopatico dell\u2019Immacolata, Istituto Dermopatico dell\u2019Immacolata (IDI-IRCCS), Rome, 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Official Gazette of the Italian Republic; 2023, No. 22."},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.07.036"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-023-00798-0"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-025-01453-8"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14092953"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19232"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2023.2224499"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3023"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19426"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-025-03328-y"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2022.29004.sna"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15688"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.5443"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-025-04278-9"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2249237"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109927"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad229"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261499632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568261499632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261499632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T16:47:16Z","timestamp":1792946836000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568261499632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":28,"alternative-id":["10.1177\/17103568261499632"],"URL":"https:\/\/doi.org\/10.1177\/17103568261499632","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"article-number":"17103568261499632"}}