{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:20:06Z","timestamp":1777789206512,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the pepsinogen C expression in malignant cutaneous melanomas and analyze its possible relationship to clinical and pathological parameters. Pepsinogen C is an aspartyl proteinase primarily involved in the digestion of proteins in the stomach and represents one of the main androgen-inducible proteins in breast cancer cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Tumoral pepsinogen C expression was retrospectively analyzed in 35 paraffin-embedded tissues from patients with primary malignant cutaneous melanoma and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi and 2 dysplastic melanocytic nevi), using immunohistochemical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The benign lesions were consistently negative for pepsinogen C, whereas 20 of the 35 malignant melanomas (57%) showed positive immunostaining for pepsinogen C. The percentage of pepsinogen C-positive tumors was significantly higher in men than in women (p=0.01) and in epithelioid melanomas than in fusocellular or mixed type melanomas (p=0.003). In addition, the percentage of pepsinogen-C positive tumors was positively and significantly correlated with lesion thickness (p=0.003), Clark's level of invasion (p=0.028) and tumor stage (p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pepsinogen C could be a new prognosticator of unfavorable outcome in cutaneous malignant melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/172460080101600403","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:37:03Z","timestamp":1520919423000},"page":"240-244","source":"Crossref","is-referenced-by-count":7,"title":["Immunohistochemical Study of Pepsinogen C Expression in Cutaneous Malignant Melanoma: Association with Clinicopathological Parameters"],"prefix":"10.1177","volume":"16","author":[{"given":"I.","family":"Quintela","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hospital de Jove, Gij\u00f3n, Asturias"},{"name":"Department of Pathology, Hospital de Jove, Gij\u00f3n, Asturias - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vizoso1","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital de Jove, Gij\u00f3n, Asturias"},{"name":"Department of Pathology, Hospital de Jove, Gij\u00f3n, Asturias - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital Virgen de los Lirios, Alcoy, Alicante"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.O.","family":"Gonz\u00e1lez1","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital de Jove, Gij\u00f3n, 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