{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:44:00Z","timestamp":1791765840852,"version":"4.3.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>The aim of the present preliminary study was to investigate the presence of free DNA (FDNA) in urine as a possible marker for the diagnosis of bladder cancer. Naturally voided morning urine specimens were collected from 57 patients with suspected bladder cancer before cystoscopy. A standard urine test was performed; the specimens were then processed in order to obtain a quantitative evaluation of the presence of free DNA in the urine. Twenty-two patients were excluded from the study because they had leukocyturia and\/or bacteriuria. Free DNA concentrations higher than 250 ng\/mL were found in all 16 patients showing bladder cancer at cystoscopy and in seven (36.8%) of the 19 patients with negative cystoscopy. Urinary FDNA seems to have an excellent sensitivity: we observed no false negative cases and 36.8% false positive cases. By contrast, only 6.25% of the bladder cancer patients had positive urine cytology. Our results seem promising, although further studies and larger numbers are needed to define urinary free DNA as a reliable marker of bladder cancer.<\/jats:p>","DOI":"10.1177\/172460080502000209","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:20:42Z","timestamp":1516062042000},"page":"134-136","source":"Crossref","is-referenced-by-count":13,"title":["Free DNA in Urine: A New Marker for Bladder Cancer? Preliminary Data"],"prefix":"10.1177","volume":"20","author":[{"given":"M.","family":"Zancan","sequence":"first","affiliation":[{"name":"ABO Association c\/o Regional Center for the Study of Biological Markers of Malignancy, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Franceschini","sequence":"additional","affiliation":[{"name":"ABO Association c\/o Regional Center for the Study of Biological Markers of Malignancy, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mimmo","sequence":"additional","affiliation":[{"name":"ABO Association c\/o Regional Center for the Study of Biological Markers of Malignancy, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vianello","sequence":"additional","affiliation":[{"name":"ABO Association c\/o Regional Center for the Study of Biological Markers of Malignancy, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Di Tonno","sequence":"additional","affiliation":[{"name":"Department of Urology, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mazzariol","sequence":"additional","affiliation":[{"name":"Department of Urology, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Malossini","sequence":"additional","affiliation":[{"name":"Department of Urology, General Regional Hospital, Venice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gion","sequence":"additional","affiliation":[{"name":"Regional Center for the Study of Biological Markers of Malignancy, General Regional Hospital, Venice - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"bibr1-172460080502000209","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-4096.2001.01699.x"},{"key":"bibr2-172460080502000209","doi-asserted-by":"publisher","DOI":"10.1177\/172460080001500118"},{"key":"bibr3-172460080502000209","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.11.008"},{"key":"bibr4-172460080502000209","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000067461.30468.6d"},{"key":"bibr5-172460080502000209","first-page":"4675","volume":"61","author":"Sozzi G.","year":"2001","journal-title":"Cancer Res"},{"key":"bibr6-172460080502000209","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1318.004"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460080502000209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460080502000209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:56:58Z","timestamp":1777492618000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/172460080502000209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1177\/172460080502000209"],"URL":"https:\/\/doi.org\/10.1177\/172460080502000209","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}