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Eosinophil migration from the bloodstream to nasal polyps is considered to be specific and is a complex process involving several different molecules such as ICAM-1, VCAM-1, and L-, P- and E-selectins. The aim of this study was to investigate, using a protein biochip array technology, the concentrations of these molecules in the peripheral blood of a group of patients affected by nasal polyposis. Patients exhibited a significantly higher expression of VCAM-1, E-selectin, and L-selectin compared to healthy controls, and Spearman's rank correlation test limited to the molecules with significant between-group differences demonstrated a significant correlation between VCAM-1 and E-selectin, VCAM-1 and L-selectin, and E-selectin and L-selectin. The results of this investigation are in line with those coming from various imunohistochemical analyses, and seem to confirm the role of inflammation in the pathogenesis of nasal polyposis. These molecules may also represent novel therapeutic targets in the treatment of nasal polyps, and may allow the selection of pharmacological prophylactics that would allow effective inhibition of the inflammation induced by a given allergen.<\/jats:p>","DOI":"10.1177\/172460080802300208","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:28:29Z","timestamp":1516062509000},"page":"115-120","source":"Crossref","is-referenced-by-count":5,"title":["Protein Biochip Array of Adhesion Molecule Expression in Peripheral Blood of Patients with Nasal Polyposis"],"prefix":"10.1177","volume":"23","author":[{"given":"M.M.","family":"Corsi","sequence":"first","affiliation":[{"name":"Institute of General Pathology, Medical Faculty, University of Milan"},{"name":"Laboratory of Applied Biotechnologies, IRCCS Galeazzi Hospital, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pagani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngological and Ophthalmological Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Dogliotti","sequence":"additional","affiliation":[{"name":"Institute of General Pathology, Medical Faculty, University of Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Perona","sequence":"additional","affiliation":[{"name":"Radiology Unit, IRCCS Galeazzi Hospital, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngological and Ophthalmological Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pignataro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngological and Ophthalmological Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"bibr1-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80142-3"},{"key":"bibr2-172460080802300208","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662255"},{"key":"bibr3-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.suppl_2.S87"},{"key":"bibr4-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900916"},{"key":"bibr5-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196903000-00010"},{"key":"bibr6-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70464-1"},{"key":"bibr7-172460080802300208","volume-title":"Minimally invasive endonasal sinus surgery.","author":"Hosemann W.","year":"2000"},{"key":"bibr8-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200407000-00013"},{"key":"bibr9-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03767.x"},{"key":"bibr10-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550220055009"},{"key":"bibr11-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100147462"},{"key":"bibr12-172460080802300208","first-page":"33","volume":"11","author":"Settipane G.","year":"1991","journal-title":"Rhinol Suppl"},{"key":"bibr13-172460080802300208","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662264"},{"key":"bibr14-172460080802300208","doi-asserted-by":"publisher","DOI":"10.2500\/105065898782103052"},{"key":"bibr15-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200302000-00001"},{"key":"bibr16-172460080802300208","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709134709"},{"key":"bibr17-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00095.x"},{"key":"bibr18-172460080802300208","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137813"},{"key":"bibr19-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70091-5"},{"key":"bibr20-172460080802300208","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90267-O"},{"key":"bibr21-172460080802300208","unstructured":"GleichG.J., KayA.B., eds. 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