{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:28:00Z","timestamp":1777789680356,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>E-cadherin (CDH1) and metalloproteinase (MMP) polymorphisms could play a crucial role in cancer invasion. Our aim was to investigate the influence of the -160C\/A CDH1, -1607ins\/delG MMP-1 and -181A\/G MMP-7 polymorphisms on the frequency and progression of colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental design<\/jats:title>\n                    <jats:p>A total of 130 patients with CRC and 130 noncancer controls were studied. The -160C\/A CDH1, -1607ins\/delG MMP-1 and -181A\/G MMP-7 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with the 1G allele and a family history of CRC showed a six times higher risk of developing CRC (OR: 6.45, 95%CI: 2.02\u201320.6, p=0.001). The A\/A CDH1 genotype was associated with a higher risk of metastatic disease (OR: 3.43, 95%CI: 1.27\u20139.27, p=0.023). A higher marginal risk of metastatic disease was observed for MMP-1 genotypes 1G\/1G and 1G\/2G (OR: 2.97, 95%CI: 0.93\u20139.47, p=0.098).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The -160C\/A CDH1, -1607ins\/delG MMP-1 and -181A\/G MMP-7 single nucleotide polymorphisms did not modify the risk of CRC development. Patients with the 1G\/1G or 1G\/2G genotype and a family history of CRC presented a higher risk of CRC. The AA CDH1 and 1G\/1G and 1G\/2G MMP-1 genotypes might be associated with advanced metastatic disease, but are not markers of lymphatic metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/172460080902400206","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:34:07Z","timestamp":1516062847000},"page":"99-106","source":"Crossref","is-referenced-by-count":13,"title":["E-Cadherin and Metalloproteinase-1 and -7 Polymorphisms in Colorectal Cancer"],"prefix":"10.1177","volume":"24","author":[{"given":"Jacqueline Miranda","family":"de Lima","sequence":"first","affiliation":[{"name":"Oncology Group, Gastroenterology Division, Federal University of Sao Paulo (UNIFESP\/EPM), Sao Paulo - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lessileia Gomes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Oncology Group, Gastroenterology Division, Federal University of Sao Paulo (UNIFESP\/EPM), Sao Paulo - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael Dale Cotrim Guerreiro","family":"da Silva","sequence":"additional","affiliation":[{"name":"Oncology Group, Gastroenterology Division, Federal University of Sao Paulo (UNIFESP\/EPM), Sao Paulo - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora Manoukian","family":"Forones","sequence":"additional","affiliation":[{"name":"Oncology Group, Gastroenterology Division, Federal University of Sao Paulo (UNIFESP\/EPM), Sao Paulo - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"bibr1-172460080902400206","unstructured":"National Center for Health Statistics. 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