{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:29:42Z","timestamp":1783646982836,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Insulin-like growth factor-II (IGF-II) is an important regulator of tumor growth in breast cancer. In this study we have examined the prognostic value of IGF-II mRNA expression in breast cancer and its relationship to other predictive parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Sixty-eight women with infiltrating ductal carcinoma were given the same treatments including mastectomy and antitumoral therapies and followed up for 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall 5-year survival rate was 73.5% (55\/68). IGF-II mRNA was expressed in 33\/64 patients (51.6%) and had no significant impact on survival. The expression of estrogen receptor (ER) and progesterone receptor (PgR) did not significantly affect the 5-year survival, but in the presence of an IGF-II mRNA signal, the survival of ER- and PgR-negative patients (n=9) was lower than that of ER- and PgR-positive patients (n=15), although the difference was not significant. The 5-year survival was not significantly different between Ki-67-positive and negative patients, but in the IGF-II positive group Ki-67-positive patients (n=7) had a significantly poorer prognosis than Ki-67-negative patients (n=26). The expression of p53 protein was associated with a poorer prognosis: 6\/11 (54.5%) p53-positive patients died in the first 26 months of follow-up and 5 of these 6 patients (83.3%) also had positive IGF-II mRNA expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IGF-II mRNA expression per se is not an independent predictive factor in breast cancer but may be a marker of poor prognosis when associated with other prognostic factors such as Ki-67 index and p53 expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/172460081002500305","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:37:17Z","timestamp":1520919437000},"page":"150-156","source":"Crossref","is-referenced-by-count":8,"title":["Igf-Ii Mrna Expression in Breast Cancer: Predictive Value and Relationship to Other Prognostic Factors"],"prefix":"10.1177","volume":"25","author":[{"given":"Emilio","family":"Fiore","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Campani","sequence":"additional","affiliation":[{"name":"Experimental Pathology, Department of Surgery, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Belardi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giustarini","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council (CNR), Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Pinchera","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Giani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Pisa, Pisa - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"bibr1-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240350102"},{"key":"bibr2-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-11-1701"},{"key":"bibr3-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1007\/BF01833331"},{"key":"bibr4-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.3.0399"},{"key":"bibr5-172460081002500305","first-page":"4978","volume":"51","author":"Cullen K.J.","year":"1991","journal-title":"Cancer Res"},{"key":"bibr6-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1007\/BF01807035"},{"key":"bibr7-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347295"},{"key":"bibr8-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.1.53"},{"key":"bibr9-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1177\/172460080201700203"},{"key":"bibr10-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1177\/030089168407000209"},{"key":"bibr11-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp082"},{"key":"bibr12-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2009.02.009"},{"key":"bibr13-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0334-7"},{"key":"bibr14-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603756"},{"key":"bibr15-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.11.845"},{"key":"bibr16-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn747"},{"key":"bibr17-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1159\/000123851"},{"key":"bibr18-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208063270606"},{"key":"bibr19-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196902)23:2<243::AID-CNCR2820230201>3.0.CO;2-9"},{"key":"bibr20-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.112"},{"key":"bibr21-172460081002500305","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196911)24:5<1071::AID-CNCR2820240533>3.0.CO;2-H"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460081002500305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460081002500305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:57Z","timestamp":1777492677000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/172460081002500305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1177\/172460081002500305"],"URL":"https:\/\/doi.org\/10.1177\/172460081002500305","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}