{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:29:17Z","timestamp":1777789757332,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. Material and methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T&gt;C (rs4646903), CYP1A1 4889 A&gt;G (rs1048943) and COMT 1947 G&gt;A (rs4680) polymorphisms were analyzed by PCR-RFLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T&gt;C) m2\/m2 genotype (OR=2.52; 95%CI=1.04\u20136.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05\u201310.87). No association between COMT 1947 G&gt;A (rs4680) or CYP1A1 4889 A&gt;G (rs1048943) and breast cancer was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that the CYP1A1 (3801 T&gt;C) m2\/m2 genotype may contribute to breast cancer susceptibility in Mexican women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/172460081002500306","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T05:37:17Z","timestamp":1520919437000},"page":"157-163","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Cyp1A1 and Comt Genotypes on Breast Cancer Risk in Mexican Women: A Pilot Study"],"prefix":"10.1177","volume":"25","author":[{"given":"M\u00f3nica","family":"Moreno-Galv\u00e1n","sequence":"first","affiliation":[{"name":"Centro Nacional de Vigilancia Epidemiol\u00f3gica y Control de Enfermedades, SSA, Mexico City - Mexico"},{"name":"Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d, SSA, Mexico City - Mexico"},{"name":"Escuela Superior de Medicina, IPN, Mexico City - Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma Estela","family":"Herrera-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, IPN, Mexico City - Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Robles-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital Regional, 1\u00b0 de Octubre SSA, Mexico City - Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"Velasco-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Regional, 1\u00b0 de Octubre SSA, Mexico City - Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Tapia-Conyer","sequence":"additional","affiliation":[{"name":"Instituto Carso, Mexico City - Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Sarti","sequence":"additional","affiliation":[{"name":"Secretaria de Salud, Mexico City - Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"bibr1-172460081002500306","unstructured":"Estad\u00edsticas a prop\u00f3sito del d\u00eda mundial contra el c\u00e1ncer. http:\/\/www.inegi.gob.mx."},{"key":"bibr2-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.427"},{"key":"bibr3-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)00382-0"},{"key":"bibr4-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6051"},{"key":"bibr5-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199606000-00007"},{"key":"bibr6-172460081002500306","first-page":"4870","volume":"59","author":"Huang C.S.","year":"1999","journal-title":"Cancer Res"},{"key":"bibr7-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0392"},{"key":"bibr8-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a123594"},{"key":"bibr9-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1007\/BF00409407"},{"key":"bibr10-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199710000-00002"},{"key":"bibr11-172460081002500306","doi-asserted-by":"publisher","DOI":"10.3109\/07357908809080645"},{"key":"bibr12-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3163-5-3"},{"key":"bibr13-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0485"},{"key":"bibr14-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199410000-00002"},{"key":"bibr15-172460081002500306","first-page":"720","volume":"48","author":"Petersen D.D.","year":"1991","journal-title":"Am J Hum Genet"},{"key":"bibr16-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1186\/bcr814"},{"key":"bibr17-172460081002500306","first-page":"4870","volume":"59","author":"Huang C.S.","year":"1999","journal-title":"Cancer Res"},{"key":"bibr18-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21056"},{"key":"bibr19-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9264-2"},{"key":"bibr20-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1177\/172460080802300104"},{"key":"bibr21-172460081002500306","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.03.025"},{"key":"bibr22-172460081002500306","doi-asserted-by":"publisher","DOI":"10.5301\/JBM.2008.4373"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460081002500306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460081002500306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:57Z","timestamp":1777492677000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/172460081002500306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1177\/172460081002500306"],"URL":"https:\/\/doi.org\/10.1177\/172460081002500306","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}