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Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET\/computed tomography in patients affected by high-grade glioma.<\/jats:p>","DOI":"10.1177\/1724600820905715","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T23:36:32Z","timestamp":1582241792000},"page":"42-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["18F-FAZA PET imaging in tumor hypoxia: A focus on high-grade glioma"],"prefix":"10.1177","volume":"35","author":[{"given":"Paola","family":"Mapelli","sequence":"first","affiliation":[{"name":"Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-6211","authenticated-orcid":false,"given":"Maria","family":"Picchio","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"bibr1-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-90005-31"},{"key":"bibr2-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9055-1"},{"key":"bibr3-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2344"},{"key":"bibr4-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006474832189"},{"key":"bibr5-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not148"},{"key":"bibr6-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.72.859.10624317"},{"key":"bibr7-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-5-528"},{"key":"bibr8-1724600820905715","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666171116123702"},{"key":"bibr9-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000286"},{"key":"bibr10-1724600820905715","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081088"},{"key":"bibr11-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802256434"},{"key":"bibr12-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4116-y"},{"key":"bibr13-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1154-5"},{"key":"bibr14-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001850"},{"key":"bibr15-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-017-0240-0"},{"key":"bibr16-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"bibr17-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1329594"},{"key":"bibr18-1724600820905715","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24234"},{"key":"bibr19-1724600820905715","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.10.010"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1724600820905715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1724600820905715","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1724600820905715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:00:05Z","timestamp":1777492805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1724600820905715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":19,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1177\/1724600820905715"],"URL":"https:\/\/doi.org\/10.1177\/1724600820905715","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}