{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:39:13Z","timestamp":1777790353497,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013060","name":"jilin provincial health and family planning commission","doi-asserted-by":"publisher","award":["2018J023"],"award-info":[{"award-number":["2018J023"]}],"id":[{"id":"10.13039\/501100013060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"science and Technology Agency of Jilin Provincial Project","award":["20200201518JC"],"award-info":[{"award-number":["20200201518JC"]}]},{"DOI":"10.13039\/501100013060","name":"jilin provincial health and family planning commission","doi-asserted-by":"publisher","award":["2017J023"],"award-info":[{"award-number":["2017J023"]}],"id":[{"id":"10.13039\/501100013060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>NTRK mutations and clinicopathological factors in patients with lung cancer in northeast China were analyzed by next-generation sequencing (NGS), and references were provided for patients with NTRK mutations undergoing targeted therapy in northeast China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 224 specimens in 173 patients with lung cancer were collected. This included 51 patients with matched tissue and whole blood samples,133 tissue samples, 84 whole blood samples, and 7 pleural effusion samples. NGS (520 genes) was used to detected NTRK mutations and clinicopathologic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>NTRK mutation was detected in eight patients (8\/173, 4.6%), including four NTRK missense mutations (4\/173, 2.3%), two NTRK fusion gene mutations (2\/173, 1.2%), and two NTRK copy number deletions (2\/173, 1.2%). Among the eight patients with NTRK mutations, four were associated with lung cancer driver gene mutations (3\/4 EGFR, 1\/4ALK); NTRK in two patients was inconsistent in tissue and paired whole blood testing; NTRK missense mutation was detected in one patient, and NTRK copy number deletion was detected in the other; and NTRK wild type was detected in two patients. There was no correlation between NTRK mutation and clinicopathologic factors (including gender, age, pathological type, smoking status, metastasis site).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NTRK mutation was only 4.6%, effective fusion gene mutation was 1.2%, and common driver gene mutation in lung cancer was evident in 50% of patients. The results of NTRK were inconsistent with matched tissues and whole blood. Therefore, patients with NTRK mutation should use a variety of specimen types and large target area sequencing (panel) analysis method to provide individualized treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1724600820949883","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T04:03:46Z","timestamp":1599883426000},"page":"36-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of NTRK mutation and clinicopathologic factors in lung cancer patients in northeast China"],"prefix":"10.1177","volume":"35","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Translational Medical Research Lab, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Yan","sequence":"additional","affiliation":[{"name":"Translational Medical Research Lab, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-7445","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Translational Medical Research Lab, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Translational Medical Research Lab, Jilin Cancer Hospital, Changchun, China"},{"name":"Department of Medical Oncology, Jilin Cancer Hospital, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"bibr1-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-0765"},{"key":"bibr2-1724600820949883","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2017.08.02"},{"key":"bibr3-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.18_suppl.LBA2501"},{"key":"bibr4-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714448"},{"key":"bibr5-1724600820949883","first-page":"2892","volume":"5","author":"Midha A","year":"2015","journal-title":"Am J Cancer Res"},{"key":"bibr6-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-43139-0_5"},{"key":"bibr7-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.248"},{"key":"bibr8-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3352"},{"key":"bibr9-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx671.004"},{"key":"bibr10-1724600820949883","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4333"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1724600820949883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1724600820949883","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1724600820949883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:00:10Z","timestamp":1777492810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1724600820949883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/1724600820949883"],"URL":"https:\/\/doi.org\/10.1177\/1724600820949883","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}