{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:39:58Z","timestamp":1777790398104,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Financing Code 001"],"award-info":[{"award-number":["Financing Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Decanato de Pesquisa e Inova\u00e7\u00e3o (DPI) UnB"},{"name":"Decanato de P\u00f3s-gradua\u00e7\u00e3o (DPG) UnB","award":["N\u00ba 0004\/2021"],"award-info":[{"award-number":["N\u00ba 0004\/2021"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Papillary thyroid cancer corresponds to approximately 1% of all carcinomas; nevertheless, it is the most prevalent endocrine neoplasm in the world. Studies reveal that the BAX (\u2212248 G\u2009&gt;\u2009A) polymorphism may be associated with negative regulation of BAX gene transcription activity, causing a decrease in its protein expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to describe the genotype and allele frequencies of BAX single nucleotide polymorphisms (\u2212248 G\u2009&gt;\u2009A) (rs4645878) in the research patients, and to associate its presence with susceptibility to papillary thyroid cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case-control study was conducted with 30 patients with papillary thyroid cancer. For the evaluation of genetic polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism technique was employed. Allele and genotype frequencies were estimated using the SPSS program, and significant associations were considered when p\u2009&lt;\u20090.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant genotypic difference between papillary thyroid cancer and the control group (p\u2009=\u20090.042). The GG genotype provided a protective factor for papillary thyroid cancer (p\u2009=\u20090.012, odds ratio (OR)\u2009=\u20090.313; confidence interval (CI)\u2009=\u20090.123\u20130.794). Likewise the G allele was a protective factor for papillary thyroid cancer (p\u2009=\u20090.009; OR\u2009=\u20090.360; CI\u2009=\u20090.163\u20130.793). The BAX gene polymorphism (\u2212248 G\u2009&gt;\u2009A) was associated with papillary thyroid cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BAX (\u2212248 G\u2009&gt;\u2009A) GG genotype carriers, or at least one mutated allele, was associated with papillary thyroid cancer in the Brazilian population studied, and the G allele presence is considered a protective factor against papillary thyroid cancer occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17246008211057576","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:31:06Z","timestamp":1637908266000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["BAX gene (\u2212248 G\u2009&gt;\u2009A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-999X","authenticated-orcid":false,"given":"Ligia C.A.","family":"Cardoso-Duarte","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Tecnologias em Sa\u00fade - Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9452","authenticated-orcid":false,"given":"Caroline F.","family":"Fratelli","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Tecnologias em Sa\u00fade - Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre S.R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Tecnologias em Sa\u00fade - Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Nayane Gomes de","family":"Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Tecnologias em Sa\u00fade - Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata de Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio do Distrito Federal (UDF), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Martins de","family":"Morais","sequence":"additional","affiliation":[{"name":"Hospital S\u00edrio-Liban\u00eas, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaor Barra","family":"Sobrinho","sequence":"additional","affiliation":[{"name":"Imagens M\u00e9dicas de Bras\u00edlia (IMEB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-0735","authenticated-orcid":false,"given":"Calliandra M.","family":"Sousa Silva","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-0344","authenticated-orcid":false,"given":"Jamila Reis","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di\u00eago Madureira de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Tecnologias em Sa\u00fade - Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-3583","authenticated-orcid":false,"given":"Izabel Cristina R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Tecnologias em Sa\u00fade - Universidade de Bras\u00edlia (UnB), Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"bibr1-17246008211057576","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S135593"},{"key":"bibr2-17246008211057576","doi-asserted-by":"publisher","DOI":"10.11606\/T.5.2016.tde-06092016-145112"},{"key":"bibr3-17246008211057576","first-page":"129","author":"Heidari Z","journal-title":"Br J Biomed Sci"},{"key":"bibr4-17246008211057576","unstructured":"INCA. 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