{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:28:30Z","timestamp":1777789710411,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:p>Correlation of structural and functional data might lead to better identification of hormone-dependent tumors. Sixty breast cancer specimens, sent to the biochemistry laboratory for estrogen receptor (ER) analysis, were studied here by a combined morpho-functional approach.<\/jats:p>\n                  <jats:p>Histological examination of needle biopsies on frozen tissue blocks showed that 12 cases (10%) were free of tumor cells; these cases mostly proved ER negative. On the other 48 cases, an immunocytochemical reaction was performed on the biopsy sections with a monoclonal antibody directed against p 29, an estrogen receptor related antigen. The staining values for p 29 and the biochemical ER findings were significantly correlated.<\/jats:p>\n                  <jats:p>A combined histological, immunocytochemical study seems to offer advantages in the selection of patients for hormonal therapy.<\/jats:p>","DOI":"10.1177\/172460088600100103","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T10:13:09Z","timestamp":1523873589000},"page":"9-14","source":"Crossref","is-referenced-by-count":2,"title":["A Combined Histological, Immunocytochemical and Biochemical Approach in the Evaluation of Estrogen Receptors in Breast Carcinomas"],"prefix":"10.1177","volume":"1","author":[{"given":"Francesca","family":"Pietribiasi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology and Institute of Pharmacology, University of Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Gugliotta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology and Institute of Pharmacology, University of Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Racca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology and Institute of Pharmacology, University of Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology and Institute of Pharmacology, University of Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bussolati","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology and Institute of Pharmacology, University of Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,1,1]]},"reference":[{"key":"bibr1-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/71.5.497"},{"key":"bibr2-172460088600100103","first-page":"1","volume":"6","author":"Underwood J.C.E.","year":"1983","journal-title":"Diagnostic Histopathol"},{"key":"bibr3-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(82)90019-0"},{"key":"bibr4-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1038\/307745a0"},{"key":"bibr5-172460088600100103","first-page":"5728","volume":"45","author":"King R.J.B.","year":"1985","journal-title":"Cancer Res"},{"key":"bibr6-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1177\/33.2.2578501"},{"key":"bibr7-172460088600100103","author":"Cano A.","year":"1986","journal-title":"Cancer Res"},{"key":"bibr8-172460088600100103","first-page":"716","volume":"109","author":"McCarty K.S.","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"bibr9-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1030287"},{"key":"bibr10-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"bibr11-172460088600100103","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430897"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460088600100103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460088600100103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:47Z","timestamp":1777492667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/172460088600100103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1177\/172460088600100103"],"URL":"https:\/\/doi.org\/10.1177\/172460088600100103","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}