{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:23:52Z","timestamp":1777789432151,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1987,5,1]],"date-time":"1987-05-01T00:00:00Z","timestamp":546825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:p>Molecular biology has shown that DNA viruses carry their own transforming genes, unlike RNA viruses (retrovirus), which use cellular \u201concogenes\u201d. Some of the products of transforming viral genes are very good potential targets for immune defence. Epstein-Barr virus (EBV) immortalization is linked to the transcriptional activation of some latently transcribed regions; the lymphocyte-determined membrane antigens (LYDMA), the product of one of these regions, are the T-cell's chosen target. EBV-induced immortalization may therefore be free from any malignant consequence as long as immortalized clones are suppressed by immunosurveillance. In vivo, LYDMA-positive clones may be susceptible to immune control; LYDMA-negative clones can transform to neoplastic cells<\/jats:p>","DOI":"10.1177\/172460088700200212","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T04:43:36Z","timestamp":1539665016000},"page":"125-132","source":"Crossref","is-referenced-by-count":2,"title":["LYDMA-antigens and Immunity against EBV-infected Cells Epstein-Barr Virus as a Model for the Study of Host-infection Interaction"],"prefix":"10.1177","volume":"2","author":[{"given":"Maria L.","family":"Villa","sequence":"first","affiliation":[{"name":"Cattedra di Immunologia, Facolt\u00e0 di Medicina, Universit\u00e0 degli Studi di Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Bombardieri","sequence":"additional","affiliation":[{"name":"Divisione di Medicina Nucleare, Istituto Nazionale per lo Studio e la Cura dei Tumori di Milano"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,5,1]]},"reference":[{"key":"bibr1-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"bibr2-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197606172942501"},{"key":"bibr3-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072030"},{"key":"bibr4-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197711172972001"},{"key":"bibr5-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91800-0"},{"key":"bibr6-172460088700200212","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-3-310"},{"key":"bibr7-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.56.6.1699"},{"key":"bibr8-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1038\/306480a0"},{"key":"bibr9-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3792.1064"},{"key":"bibr10-172460088700200212","volume-title":"Viruses Associated with Human Cancer.","author":"Pagano J.S.","year":"1983"},{"key":"bibr11-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60339-9"},{"key":"bibr12-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072073"},{"key":"bibr13-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(81)90504-3"},{"key":"bibr14-172460088700200212","first-page":"133","volume":"3","author":"Kief E.","year":"1983","journal-title":"Adv Viral Oncol"},{"key":"bibr15-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1038\/315190a0"},{"key":"bibr16-172460088700200212","first-page":"4222","volume":"41","author":"Henle W.","year":"1981","journal-title":"Cancer Res"},{"key":"bibr17-172460088700200212","volume-title":"Mechanisms of B-cell neoplasia, 1985.","author":"Melchers F.","year":"1985"},{"key":"bibr18-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.23.8153"},{"key":"bibr19-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1038\/310145a0"},{"key":"bibr20-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80098-2"},{"key":"bibr21-172460088700200212","doi-asserted-by":"publisher","DOI":"10.1038\/318287a0"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460088700200212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460088700200212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:56:49Z","timestamp":1777492609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/172460088700200212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["10.1177\/172460088700200212"],"URL":"https:\/\/doi.org\/10.1177\/172460088700200212","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}