{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:42:22Z","timestamp":1777790542712,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p>\n                    We assayed prostatic specific antigen (PSA) and prostatic acid phosphatase (PAP) serum levels in 1383 patients using a double antibody radioimmunoassay (RIA) I\n                    <jats:sup>125<\/jats:sup>\n                    . Establishing the upper normal limit in 10 ng\/ml PSA and 2.5 ng\/ml for PAP, the false positive results were only 1.9 and 5.1 percent in men with non-prostatic benign or malignant pathology and respectively 0 and 2.2 percent in women. We detected false positive levels for these two tumoral markers in 3.5 and 4.7 percent of patients with non-complicated benign prostatic hypertrophy, 64.8 and 19.2 percent in complicated benign prostatic hypertrophy, 24 and 16 percent in acute prostatitis and 3.3 percent in chronic prostatitis.\n                  <\/jats:p>\n                  <jats:p>The sensitivity in patients with prostate cancer was 87.2 percent for PSA and 64.1 percent for PAP, and there was a better correlation with PSA than PAP for tumoral spread and histological grading. Finally, clinical efficacy was higher with PSA and was no better when both markers were assayed.<\/jats:p>","DOI":"10.1177\/172460088900400205","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T04:41:07Z","timestamp":1539664867000},"page":"87-94","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Behaviour of Prostatic Specific Antigen and Prostatic Acid Phosphatase: A Comparative Study"],"prefix":"10.1177","volume":"4","author":[{"given":"J. Morote","family":"Robles","sequence":"first","affiliation":[{"name":"Services of Urology and Nuclear Medicine Tumor Markers Unit, C.S. Vall d'Hebron, Barcellona - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Ruibal","family":"Morell","sequence":"additional","affiliation":[{"name":"Services of Urology and Nuclear Medicine Tumor Markers Unit, C.S. Vall d'Hebron, Barcellona - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"De Torres Mateos","sequence":"additional","affiliation":[{"name":"Services of Urology and Nuclear Medicine Tumor Markers Unit, C.S. Vall d'Hebron, Barcellona - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Soler","family":"Rosell\u00f3","sequence":"additional","affiliation":[{"name":"Services of Urology and Nuclear Medicine Tumor Markers Unit, C.S. Vall d'Hebron, Barcellona - Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"bibr1-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)65503-4"},{"key":"bibr2-172460088900400205","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.4049\/jimmunol.104.6.1329","volume":"104","author":"Ablin R.J.","year":"1970","journal-title":"J Immunol"},{"key":"bibr3-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197206)29:6<1570::AID-CNCR2820290621>3.0.CO;2-V"},{"key":"bibr4-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/19.7.786"},{"key":"bibr5-172460088900400205","first-page":"105","volume":"59","author":"Moncure C.W.","year":"1975","journal-title":"Cancer Chemother Rep"},{"key":"bibr6-172460088900400205","first-page":"159","volume":"17","author":"Wang M.C.","year":"1979","journal-title":"Invest Urol"},{"key":"bibr7-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1159\/000225594"},{"key":"bibr8-172460088900400205","first-page":"406","volume":"42","author":"Ban Y.","year":"1983","journal-title":"Fed Proc"},{"key":"bibr9-172460088900400205","first-page":"37","volume":"66","author":"Papsidero L.D.","year":"1981","journal-title":"J Natl Cancer Inst"},{"key":"bibr10-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810901)48:5<1229::AID-CNCR2820480529>3.0.CO;2-L"},{"key":"bibr11-172460088900400205","first-page":"2428","volume":"40","author":"Papsidero L.D.","year":"1983","journal-title":"Cancer Res"},{"key":"bibr12-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.1983.2.139"},{"key":"bibr13-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.3.903"},{"key":"bibr14-172460088900400205","first-page":"3714","volume":"42","author":"Frankel A.E.","year":"1982","journal-title":"Cancer Res"},{"key":"bibr15-172460088900400205","first-page":"207","volume":"21","author":"Kurijama M.","year":"1980","journal-title":"Proc Am Assoc Cancer Res"},{"key":"bibr16-172460088900400205","first-page":"4658","volume":"40","author":"Kuriyama M.","year":"1980","journal-title":"Cancer Res"},{"key":"bibr17-172460088900400205","first-page":"99","volume":"68","author":"Kuriyama M.","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"bibr18-172460088900400205","first-page":"1057","volume":"30","author":"Seamonds B.","year":"1984","journal-title":"Clin Chem"},{"key":"bibr19-172460088900400205","first-page":"1057","volume":"30","author":"Yang N.","year":"1984","journal-title":"Clin Chem"},{"key":"bibr20-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/30.5.649"},{"key":"bibr21-172460088900400205","first-page":"562","volume":"38","author":"Morote J.","year":"1985","journal-title":"Arch Esp Urol"},{"key":"bibr22-172460088900400205","unstructured":"RuibalA., MoroteJ., EncaboG., Genoll\u00e1J., de TorresJ.A. Prostatic specific antigen (PSA) seric levels in patients having prostatic pathologies. XIII Annual meeting of the International Society for Oncodevelopment Biology and Medicine. Paris 1985."},{"key":"bibr23-172460088900400205","volume-title":"SPSS User's GuMe.","author":"Norsis M.J.","year":"1983"},{"key":"bibr24-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930240219"},{"key":"bibr25-172460088900400205","unstructured":"KuriyamaM., TakeuchiT., OkanoM.  Clinical evaluation of prostatic antigen in Japanese urological cancer patients. Congress of International Society of Urology Vienna 1985; 145."},{"key":"bibr26-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)53915-4"},{"key":"bibr27-172460088900400205","first-page":"984","volume":"31","author":"Chen T.W.","year":"1985","journal-title":"Clin Chem"},{"key":"bibr28-172460088900400205","first-page":"984","volume":"31","author":"Loor R.","year":"1985","journal-title":"Clin Chem"},{"key":"bibr29-172460088900400205","first-page":"3874","volume":"41","author":"Kuriyama M.","year":"1981","journal-title":"Cancer Res"},{"key":"bibr30-172460088900400205","first-page":"1253","volume":"29","author":"Killian C.S.","year":"1983","journal-title":"Clin Chem"},{"key":"bibr31-172460088900400205","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)53431-X"},{"key":"bibr32-172460088900400205","volume-title":"Value of prostate specific antigen and prostatic acid phosphatase in monitoring prostate cancer.","author":"Morote J.","year":"1986"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460088900400205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/172460088900400205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:00:41Z","timestamp":1777492841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/172460088900400205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1177\/172460088900400205"],"URL":"https:\/\/doi.org\/10.1177\/172460088900400205","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}