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Reactivity to MAbs B72.3, CC49, CC83 (anti TAG 72), COL-12 (anti CEA) and MOv2 (against a tumor-associated mucoprotein) was restricted to &lt; 50% of the tumors studied, while MAbs B1.1 (anti CEA), MBrl and MBr8 (to tumor-associated carbohydrates) reacted with &gt; 50% of the cases. Correlations between expression of TAAs and proliferative activity showed that the tumors could be divided into three groups, two characterized by either high proliferative activity and absence of antigenic expression or low proliferative activity and strong antigenic expression, and the third showing no relation between these two biological features. We defined two antigenic phenotypes associated with specific cellular kinetics: one characterized by negative immunoreaction with MAbs, CC49, CC83 and COL-12 and high proliferative activity; the other characterized by intense immunoreactivity with these antibodies and low proliferative activity. The data suggest that cell proliferation and antigenic phenotype may define biologic subsets of breast carcinomas<\/jats:p>","DOI":"10.1177\/172460089100600304","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T13:59:01Z","timestamp":1520949541000},"page":"159-166","source":"Crossref","is-referenced-by-count":1,"title":["Cell Kinetics and Tumor-Associated Antigen Expression in Human Mammary Carcinomas"],"prefix":"10.1177","volume":"6","author":[{"given":"A.","family":"Contegiacomo","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, La Sapienza University of Roma, Roma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Mariani","family":"Costantini","sequence":"additional","affiliation":[{"name":"Institutes of Human Pathology and Social Medicine, G. 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