{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:08:08Z","timestamp":1782202088825,"version":"3.54.5"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Trials"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Background\u2003There is substantial need to rigorously evaluate existing and new therapies for pulmonary arterial hypertension (PAH) and other severe and relatively rare conditions affecting younger patients. However, the ability to conduct meaningful randomized clinical trials (RCTs) in such contexts often is limited by difficulties obtaining adequate patient enrollment.<\/jats:p>\n                  <jats:p>Purpose \u2003To understand the motivations of patients with PAH for participating in RCTs so as to facilitate enrollment in future trials among patients with similar diseases.<\/jats:p>\n                  <jats:p>Methods \u2003We conducted semistructured interviews of a diverse sample of patients with World Health Organization (WHO) Group I PAH. We purposefully recruited a diverse sample of participants until theoretical saturation was reached. We randomly assigned patients to review hypothetical RCTs that did or did not allow continuation of background PAH therapies and elicited their reasons for or against enrolling. Interviews were transcribed and analyzed using constant comparison techniques to code and sort data into discrete themes.<\/jats:p>\n                  <jats:p>Results\u2003The 26 PAH patients enrolled before theoretical saturation was reached identified 24 factors that would influence their RCT enrollment decisions. These factors grouped naturally into four themes: (1) personal medical benefits, (2) personal medical risks\/harms, (3) nonmedical benefits, and (4) nonmedical burdens. Personal benefits were cited as commonly as altruistic motives. One third of the patients (9\/26) suggested that they would defer enrollment decisions to their treating clinicians. Seventy-nine percent of patients (11\/14) assigned to consider trials without background therapies expressed concerns about clinical deterioration (vs. 17% (2\/12) among patients assigned to consider trials allowing background therapies).<\/jats:p>\n                  <jats:p>Limitations\u2003The sample was recruited from a single academic center. Furthermore, the use of hypothetical trials may not elicit identical decision-making processes as may be used among patients contemplating actual trial participation.<\/jats:p>\n                  <jats:p>Conclusion\u2003For PAH patients considering RCT enrollment, the potentials for personal benefit and risk are at least as important as altruistic motives. Minimizing the time demands of participating, financial remuneration, and allowing participants to continue current therapies are factors, which might enhance enrollment to trials in similar disease areas.<\/jats:p>","DOI":"10.1177\/1740774512438981","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T11:59:33Z","timestamp":1330948773000},"page":"348-357","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Motivations of patients with pulmonary arterial hypertension to participate in randomized clinical trials"],"prefix":"10.1177","volume":"9","author":[{"given":"Ricki","family":"Carroll","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Antigua","sequence":"additional","affiliation":[{"name":"Department of Medicine, University 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