{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:13:28Z","timestamp":1777544008047,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Trials"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>Understanding the influence or impact of epidemiological factors on cancer outcomes in clinical trials can broaden our knowledge of disease, trial populations and therapeutic effects thus leading to improved patient care. However, there is a lack of data on cancer patients\u2019 compliance with an epidemiology questionnaire in the context of a clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Cancer patients were provided with a hypothetical scenario and surveyed regarding their willingness and preferences to complete an epidemiology questionnaire if incorporated into a cancer therapy trial. Patient compliance with completing a voluntary epidemiology questionnaire and trial coordinators perceptions therein were separately determined in the NCIC Clinical Trials Group HN.6 clinical trial, an ongoing randomized phase III trial comparing two first-line treatment regimens in patients with locoregionally advanced head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 617 cancer patients from community, academic and tertiary cancer centres, the majority were willing to complete an epidemiology questionnaire either unconditionally (45%), or provided it did not inconvenience them (31%); 4% would refuse. Patients preferred shorter questionnaires of 30\u201350 questions requiring 10\u201320\u2009min to complete, administered over 1\u20133 sessions. Patients were less willing, but still compliant, to answer questions relating to sexual history (71%) and annual household income (66%) relative to other questions (&gt;90%). Eighteen percent thought that the questionnaire should be mandatory, with 31% believing that they may benefit personally from such research. In the HN.6 trial, compliance averaged 94.8% per question.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cancer patients are very willing to complete epidemiology questions in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1740774514568689","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T01:37:18Z","timestamp":1422581838000},"page":"237-245","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer patients\u2019 acceptability of incorporating an epidemiology questionnaire within a clinical trial"],"prefix":"10.1177","volume":"12","author":[{"given":"Sinead","family":"Cuffe","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"},{"name":"HOPE Directorate, St. James\u2019s Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Hon","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Tobros","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Espin-Garcia","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonathan","family":"Brhane","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Harland","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab","family":"Fadhel","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawson","family":"Eng","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"LaDelfa","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Waldron","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian L","family":"Siu","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingshu E","family":"Chen","sequence":"additional","affiliation":[{"name":"NCIC Clinical Trials Group, Queen\u2019s University, Kingston, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, 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