{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:01:29Z","timestamp":1792800089846,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002553"],"award-info":[{"award-number":["UL1TR002553"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002733"],"award-info":[{"award-number":["UL1TR002733"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR003096"],"award-info":[{"award-number":["UL1TR003096"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association of Clinical Research Professionals","id":[{"id":"https:\/\/ror.org\/02k46hk39","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Trials"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>The clinical and translational research enterprise is recognized by many as the \u201cevidence generation system.\u201d While there have been several calls to revolutionize this enterprise to more effectively deliver the fruits of biomedical science to patients and society, significant issues across the clinical research workforce are pervasive. Perhaps the most visible sign is the widening gap between supply and demand for competent staff. Underpinning this, is a perfect storm of complex issues. Now reaching crisis point, this problem is far bigger than a staffing issue and ultimately jeopardizes the \u201cengine\u201d of drug and device development. With the current perilous state of the workforce, proposed enterprise fixes are likely to languish far out of reach, given that even \u201cbusiness as usual\u201d is under threat. In fact, a glaring disconnect is evident between the visionary discourse on how to revolutionize the clinical research enterprise and the sober recognition that operationalization of any such vision rests on the shoulders of a workforce that\u2019s in dire straits. In this article, we provide a brief forensic analysis of the workforce problem and an initial indication of where solutions may lie.<\/jats:p>","DOI":"10.1177\/17407745231177885","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T08:23:27Z","timestamp":1685694207000},"page":"457-462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Now is the time to fix the clinical research workforce crisis"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8525-3271","authenticated-orcid":false,"given":"Stephanie A","family":"Freel","sequence":"first","affiliation":[{"name":"Duke Office of Clinical Research, Duke University School of Medicine and Duke Clinical Translational Science Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise C","family":"Snyder","sequence":"additional","affiliation":[{"name":"Duke Office of Clinical Research, Duke University School of Medicine and Duke Clinical Translational Science Institute, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Bastarache","sequence":"additional","affiliation":[{"name":"Association of Clinical Research Professionals, Alexandria, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-7860","authenticated-orcid":false,"given":"Carolynn Thomas","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, College of Nursing, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B","family":"Marchant","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A","family":"Rowley","sequence":"additional","affiliation":[{"name":"North Carolina Biotechnology Center, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A","family":"Sonstein","sequence":"additional","affiliation":[{"name":"Multi-Regional Clinical Trials Center of Brigham and Women\u2019s and Harvard, Cambridge MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M","family":"Lipworth","sequence":"additional","affiliation":[{"name":"Association of Clinical Research Professionals, Alexandria, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P","family":"Landis","sequence":"additional","affiliation":[{"name":"Association of Clinical Research Professionals, Alexandria, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"bibr1-17407745231177885","doi-asserted-by":"publisher","DOI":"10.1177\/17407745221147689"},{"key":"bibr2-17407745231177885","unstructured":"Clinical Trials Administrator Archives. 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