{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:46:43Z","timestamp":1773809203972,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p> Objectives: To assess the effects of long-term beta blockers in patients with stable angina. <\/jats:p><jats:p> Methods: We reviewed the literature up to June 2010 from CENTRAL, MEDLINE, EMBASE, CBM, and CNKI for randomized controlled trials. The appropriate data were meta-analysed using Revman 5.0. <\/jats:p><jats:p> Results: Twenty-six trials including 6108 patients were identified. The treatment with beta blockers has significantly decreased all-cause mortality when compared with no control (OR 0.40, 95% CI 0.20 to 0.79), but has had no statistically differences when compared with placebo (OR 0.92, 95% CI 0.62 to 1.38) and with calcium-channel blocker (CCB) (OR 0.84, 95% CI 0.49 to 1.44). This was similar in patients with fatal and non-fatal acute myocardial infarction when compared with placebo (OR 0.82, 95% CI 0.57 to 1.17) or CCB (OR 1.08, 95% CI 0.71 to 1.66); on revascularization and quality of life. The beta blockers reduced the incident of unstable angina compared to no treatment (OR 0.14, 95% CI 0.07 to 0.29), but increased unstable angina compared to placebo (OR 3.32, 95% CI 1.50 to 7.36). There was a significant reduction of nitrate consumption when beta blockers were compared with CCBs (OR \u22121.18, 95% CI \u22121.54 to \u22120.82), but not with placebo and trimetazidine. There was no significant difference in angina attack between each group. Side effects in beta blocker were similar with ones in controls. <\/jats:p><jats:p> Conclusions: Beta blockers may decrease the death and unstable angina when compared with no treatment, but no more effective than other anti-anginal agents on prophylaxis of myocardial ischaemia in stable angina patients. <\/jats:p>","DOI":"10.1177\/1741826711409325","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T00:45:38Z","timestamp":1303951538000},"page":"330-341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Long-term beta blockers for stable angina: systematic review and meta-analysis"],"prefix":"10.1093","volume":"19","author":[{"given":"De Fen","family":"Shu","sequence":"first","affiliation":[{"name":"Geriatrics, West China Hospital, Sichuan University, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi Rong","family":"Dong","sequence":"additional","affiliation":[{"name":"Geriatrics, West China Hospital, Sichuan University, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu Fang","family":"Lin","sequence":"additional","affiliation":[{"name":"Geriatrics, West China Hospital, Sichuan University, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Chinese Cochrane Centre, Chinese EBM Centre, West China Hospital, Sichuan University, Chengdu, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Cochrane Centre, Chinese EBM Centre, West China Hospital, Sichuan University, Chengdu, 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