{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:22:08Z","timestamp":1791390128697,"version":"4.3.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T00:00:00Z","timestamp":1312243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Prev Cardiolog"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Background and design: The effects of aspirin on blood pressure (BP) are controversial and a chronopharmacological effect of aspirin on 24-hour BP was reported recently in otherwise untreated hypertensive patients. The study was designed to test the timing effect of aspirin dosing on 24-hour BP in treated hypertensive patients routinely taking aspirin for cardiovascular prevention.<\/jats:p><jats:p>Method and results: Seventy-five patients were randomized into two groups. One group was to receive aspirin in the evening then in the morning for 1 month and the other group in the morning then in the evening, following a cross-over design. The principal assessment criterion was 24-hour systolic BP (SBP) measured by 24-hour ambulatory BP monitoring (ABPM). Patients were aged 65\u2009\u00b1\u20099 years and had been hypertensive for 12\u2009\u00b1\u200910 years. They were all taking a mean of 2.8 antihypertensive drugs and did not modify their treatment throughout the study. Of the included subjects, 70% were men and 33% were diabetics. Mean 24-hour SBP values were clinically equivalent and were not statistically different, depending on whether the aspirin was taking in the morning or evening (128.3\u2009\u00b1\u20091.4 vs. 128.3\u2009\u00b1\u20091.4\u2009mmHg, respectively). Neither was there any significant difference in diurnal and nocturnal SBP or in 24-hour, diurnal, and nocturnal diastolic BP (DBP).<\/jats:p><jats:p>Conclusion: It does not appear useful to advise patients with long-standing hypertension to modify timing of aspirin intake in order to reduce BP values.<\/jats:p>","DOI":"10.1177\/1741826711418165","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:55:32Z","timestamp":1312332932000},"page":"706-711","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Is there a BP benefit of changing the time of aspirin administration in treated hypertensive patients?"],"prefix":"10.1093","volume":"19","author":[{"given":"Yves","family":"Dimitrov","sequence":"first","affiliation":[{"name":"Club des jeunes hypertensiologues, Haguenau, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Baguet","sequence":"additional","affiliation":[{"name":"Club des jeunes hypertensiologues, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Hottelart","sequence":"additional","affiliation":[{"name":"Club des jeunes hypertensiologues, Limoges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marboeuf","sequence":"additional","affiliation":[{"name":"Club des jeunes hypertensiologues, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Tartiere","sequence":"additional","affiliation":[{"name":"Club des jeunes hypertensiologues, Toulon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ducher","sequence":"additional","affiliation":[{"name":"Club des jeunes hypertensiologues, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Fauvel","sequence":"additional","affiliation":[{"name":"Club des jeunes hypertensiologues, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,2]]},"reference":[{"key":"bibr1-1741826711418165","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03539-X"},{"key":"bibr2-1741826711418165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(97)11475-1","volume":"351","author":"Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased 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