{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:23:54Z","timestamp":1777944234549,"version":"3.51.4"},"reference-count":76,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Shear wave elastography has been increasingly used as a supplementary tool to assess diffuse thyroid disease. This study aimed to evaluate thyroid shear wave velocity in healthy children, determine the optimal number of shear wave velocity measurements and establish a diagnostic cut-off value to aid in the detection of diffuse thyroid disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We retrospectively analysed children (&lt;16\u2009years) who underwent thyroid ultrasound between 2019 and 2021. Both those with and without thyroid pathology were included consecutively. Shear wave elastography was performed, and 6 and 10 shear wave velocity measurements (m\/s) were obtained from the right and left lobes, respectively. Analyses included Student\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, Pearson\u2019s correlation, receiver operating characteristic curve and Fagan nomogram.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 194 children, 144 controls had normal ultrasound findings, while 50 diffuse thyroid disease cases showed echostructural abnormalities in 84%. Shear wave velocity was higher in the diffuse thyroid disease group (2.09\u2009\u00b1\u20090.34\u2009(1.42\u20132.88)\u2009m\/s) than controls (1.75\u2009\u00b1\u20090.21\u2009(1.38\u20132.47)\u2009m\/s) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The area under the curve was 0.805\u2009\u00b1\u20090.041 (0.725\u20130.884); shear wave velocity\u2009&lt;\u20091.75\u2009m\/s was associated with a low probability of diffuse thyroid disease (8% (4\u201314%)). Accuracy fell significantly when measurements were reduced from 10 to 6 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No laboratory tests confirmed euthyroid status in controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Ten shear wave velocity measurements were recommended for optimal shear wave elastography evaluation. A shear wave velocity\u2009&lt;\u20091.75\u2009m\/s suggested a low probability of diffuse thyroid disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1742271x251389553","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:09:02Z","timestamp":1765436942000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Thyroid sonoelastography in paediatrics: A comparison between healthy and diffuse thyroid disease"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-6854","authenticated-orcid":false,"given":"Marta","family":"Tovar P\u00e9rez","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan de Dios","family":"Berna Mestre","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Enrique","family":"Fern\u00e1ndez Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Mar\u00eda","family":"S\u00e1nchez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Serrano Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Navarro S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Guzm\u00e1n Aroca","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0493"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.2715"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.14366\/usg.17031"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0486"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-017-0788-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-020-00437-y"},{"key":"e_1_3_2_8_2","first-page":"183","article-title":"Hipotiroidismo y bocio","volume":"1","author":"Ares Segura S","year":"2019","unstructured":"Ares Segura S, Rodr\u00edguez S\u00e1nchez A, Alija Merillas M, et al. 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