{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:04:52Z","timestamp":1790233492080,"version":"4.1.0"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801719"],"award-info":[{"award-number":["81801719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Liver metastasis from hepatoid adenocarcinoma of the sigmoid colon is a rare clinical case with atypical clinical symptoms, a high degree of malignancy, and a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>A 28-year-old male presented with recurrent upper abdominal pain. Abdominal computed tomography revealed a hepatic mass. Laboratory tests showed markedly elevated alpha-fetoprotein (72,020 ng\/mL) with negative hepatitis markers. Conventional ultrasound revealed multiple hepatic masses, some of which were hyperechoic. Contrast-enhanced ultrasound demonstrated a \u201cfast-in and fast-out\u201d enhancement pattern, supporting the impression of metastatic liver disease and prompting further investigation for an extrahepatic primary source, which was subsequently confirmed by colonoscopy, liver biopsy, and immunohistochemistry as hepatoid adenocarcinoma of the sigmoid colon with liver metastasis (stage IVA, pT4aN2bM1). The patient received systemic chemotherapy (initially FOLFIRI plus cetuximab, then bevacizumab plus mFOLFOX6 upon progression), achieving rapid alpha-fetoprotein decline and significant tumor shrinkage initially, followed by stabilisation on the second-line regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case highlights the diagnostic value of contrast-enhanced ultrasound in alpha-fetoprotein\u2013elevated hepatic lesions and the role of alpha-fetoprotein as a monitoring biomarker. Multimodal evaluation\u2014integrating imaging, laboratory, histopathological, and immunohistochemical findings\u2014is essential for accurate diagnosis and therapeutic guidance in this rare malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1742271x261480040","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:03:32Z","timestamp":1789988612000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver metastasis from hepatoid adenocarcinoma of the sigmoid colon: A case report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6057","authenticated-orcid":false,"given":"Long","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"7","key":"e_1_3_2_2_2","first-page":"710","article-title":"Metastatic gastrointestinal hepatoid adenocarcinoma of the liver: a high-grade carcinoma that is easily confused with primary hepatocellular carcinoma","volume":"49","author":"Lou KX","year":"2020","unstructured":"Lou KX, Fu Y, Wu HY, et al. Metastatic gastrointestinal hepatoid adenocarcinoma of the liver: a high-grade carcinoma that is easily confused with primary hepatocellular carcinoma. Zhonghua Bing Li Xue Za Zhi 2020; 49(7): 710\u2013714.","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23595"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05488-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07031-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02773-9"},{"issue":"3","key":"e_1_3_2_7_2","article-title":"Exceptional long-term survival of a patient with hepatoid adenocarcinoma of the colon and the treatment strategy: a case report","volume":"16","author":"Jiang H","year":"2024","unstructured":"Jiang H, Fang G, Zhang J. Exceptional long-term survival of a patient with hepatoid adenocarcinoma of the colon and the treatment strategy: a case report. Cureus 2024; 16(3): e55620.","journal-title":"Cureus"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.633916"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101200100016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216104"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.635537"}],"container-title":["Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1742271X261480040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1742271X261480040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1742271X261480040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:46:17Z","timestamp":1790232377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1742271X261480040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":10,"alternative-id":["10.1177\/1742271X261480040"],"URL":"https:\/\/doi.org\/10.1177\/1742271x261480040","relation":{},"ISSN":["1742-271X","1743-1344"],"issn-type":[{"value":"1742-271X","type":"print"},{"value":"1743-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"article-number":"1742271X261480040"}}