{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:43:51Z","timestamp":1777495431177,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Illness"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Subsequent limb amputation (SLA) may be necessary due to disease progression, infection, or to aid prosthesis fit. SLA in Saskatchewan has increased 3.2% from 2006 to 2019 with minor SLA increasing 9.6% during that period. Diabetes affects a large proportion of patients who require SLA; however, the impact of additional comorbidities is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>First-episode subsequent lower extremity limb amputation (SLEA) cases with the presence\/absence of diabetes, other comorbidities, and demographic characteristics from 2006\u20132019 were retrieved from Saskatchewan's Discharge Abstract Database. Logistic regression was performed to examine the magnitude of the odds of SLEA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 956 first-episode SLEA patients investigated, 78.8% were diagnosed with diabetes. Of these, 76.1% were male and 83.0% were aged 50\u2009+\u2009years. Three comorbidities: renal failure (AOR\u2009=\u20091.9, 95% Cl 1.1\u2009\u2212\u20093.0), hypertension (AOR\u2009=\u20093.0, 95% Cl 2.0\u2009\u2212\u20094.5), and congestive heart failure (AOR\u2009=\u20092.0, 95% CI 1.2\u2009\u2212\u20093.2), conferred the highest odds of SLEA. The odds of SLEA is greatest for those aged 50\u201369 years, males, Registered Indians, and associated with a prolonged hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These data are important as they may help medical providers identify patients at the highest risk of SLEA and target interventions to optimize outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17423953221137891","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T01:22:15Z","timestamp":1668129735000},"page":"779-790","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comorbidity and risk factors of subsequent lower extremity amputation in patients diagnosed with diabetes in Saskatchewan, Canada"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-3025","authenticated-orcid":false,"given":"Samuel Kwaku","family":"Essien","sequence":"first","affiliation":[{"name":"School of Rehabilitation Science, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Zucker-Levin","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"bibr1-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-021-00759-1"},{"key":"bibr2-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2020.05.013"},{"key":"bibr3-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2020.06.026"},{"key":"bibr4-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1007\/s40141-014-0063-0"},{"key":"bibr5-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002325"},{"key":"bibr6-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2021.10.030"},{"key":"bibr7-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.06.072"},{"key":"bibr8-17423953221137891","doi-asserted-by":"publisher","DOI":"10.3109\/03093648009164567"},{"key":"bibr9-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.10.063"},{"key":"bibr10-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1177\/1534734609334808"},{"key":"bibr11-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.09.010"},{"key":"bibr12-17423953221137891","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2337"},{"key":"bibr13-17423953221137891","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-021-01381-2"},{"key":"bibr14-17423953221137891","unstructured":"Diabetes in Canada. 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