{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:10:38Z","timestamp":1791900638684,"version":"4.3.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Illness"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the presence of chronic critical illness (CCI) in COVID-19 patients and compare clinical characteristics and prognosis of patients with and without CCI admitted to intensive care unit (ICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>It was a retrospective, observational study at a university hospital ICU. Patients were accepted as CCI if they had prolonged ICU stay (\u226514 days) and got \u22651 score for cardiovascular sequential organ failure assessment (SOFA) score and \u22652 score in other parameters on day 14 of ICU admission which was described as persistent organ dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      131 of 397 (33%) patients met CCI criteria. CCI patients were older ( p\u2009=\u20090.003) and frailer ( p\u2009&lt;\u20090.001). Their Acute Physiology and Chronic Health Evaluation (APACHE) II and SOFA scores were higher, PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio was lower ( p\u2009&lt;\u20090.001). Requirement of invasive mechanical ventilation (IMV), steroid use, and septic shock on admission were higher in the CCI group ( p\u2009&lt;\u20090.001). CCI patients had higher ICU and hospital mortality than other patients (54.2% vs. 19.9% and 55.7% vs. 22.6%, p\u2009&lt;\u20090.001, respectively). Regression analysis revealed that IMV (OR: 8.40, [5.10\u201313.83], p\u2009&lt;\u20090.001) and PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO2\u2009&lt;\u2009150 on admission (OR: 2.25, [1.36\u20133.71], p\u2009=\u20090.002) were independent predictors for CCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>One-third of the COVID-19 patients admitted to the ICU were considered as CCI with significantly higher ICU and hospital mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17423953231161333","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T02:34:23Z","timestamp":1678242863000},"page":"86-95","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Chronic critical illness in critically ill COVID-19 patients"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-7438","authenticated-orcid":false,"given":"Burcin","family":"Halacli","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esat Kivanc","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ege","family":"Ulusoydan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru Ortac","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Topeli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"bibr1-17423953231161333","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000762"},{"key":"bibr2-17423953231161333","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2018.06.002"},{"key":"bibr3-17423953231161333","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0210CI"},{"key":"bibr4-17423953231161333","volume":"146","author":"Desarmenien M","year":"2016","journal-title":"Swiss Med Wkly"},{"key":"bibr5-17423953231161333","first-page":"339","volume":"30","author":"Girard K","year":"1985","journal-title":"Respir 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