{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:47:15Z","timestamp":1777495635253,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Illness"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemodialysis patients are common to have renal anemia in the nephrology practice. For the renal anemia, the high-dose iron from the intravenous route is an important treatment option. We can understand the treatment effects and cardiovascular events of high-dose intravenous iron reviewing the randomized clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the high-dose and low-dose iron treatments to find if the high-dose intravenous iron can influence the hematological parameters more significantly than the low-dose iron. The cardiovascular events were also analyzed for the high-dose iron treatment. Six studies with a total of 2422 renal anemia patients under hemodialysis were enrolled. We focused the outcomes of hemoglobin, transferrin saturation percentage, ferritin, erythropoietin dose, and cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The high-dose intravenous iron might be associated with a greater number of ferritin, transferrin saturation percentage, and hemoglobin. In addition, the erythropoietin dose was less needed to maintain the ideal hemoglobin range in the high-dose intravenous iron group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In current meta-analysis, the high-dose intravenous iron might show the superior effects on the ferritin, transferrin saturation percentage, and hemoglobin levels and needed dose of erythropoietin when compared to low-dose iron treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17423953231180453","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T03:07:51Z","timestamp":1686107271000},"page":"221-232","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The treatment effects and cardiovascular events of high-dose intravenous iron for hemodialysis patients with renal anemia: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"20","author":[{"given":"Shanbao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shanghai Pudong New District Punan Hospital, Shanghai, China Shanghai Punan Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The first People's Hospital of JiangXia District, Wuhan City, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-0386","authenticated-orcid":false,"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chongqing Three Gorges Central Hospital, Chongqing University Three Gorges Hospital, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"bibr1-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02273-4"},{"key":"bibr2-17423953231180453","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03850321"},{"key":"bibr3-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12558"},{"key":"bibr4-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810742"},{"key":"bibr5-17423953231180453","doi-asserted-by":"publisher","DOI":"10.5414\/CN109512"},{"key":"bibr6-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.09.028"},{"key":"bibr7-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-1916-8"},{"key":"bibr8-17423953231180453","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03370414"},{"key":"bibr9-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01826-3"},{"key":"bibr10-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.6.1239"},{"key":"bibr11-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.11.001"},{"key":"bibr12-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V113530"},{"key":"bibr13-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1159\/000046676"},{"key":"bibr14-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007050606"},{"key":"bibr15-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1080\/08860220802599106"},{"key":"bibr16-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv142"},{"key":"bibr17-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq858"},{"key":"bibr18-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.10.002"},{"key":"bibr19-17423953231180453","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05390517"},{"key":"bibr20-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa212"},{"key":"bibr21-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1196-7"},{"key":"bibr22-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12078"},{"key":"bibr23-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236277"},{"key":"bibr24-17423953231180453","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01490506"},{"key":"bibr25-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87401-w"},{"key":"bibr26-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.299"},{"key":"bibr27-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft062"},{"key":"bibr28-17423953231180453","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.20.015"},{"key":"bibr29-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1159\/000113529"},{"key":"bibr30-17423953231180453","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009206"}],"container-title":["Chronic 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