{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:14:23Z","timestamp":1791562463213,"version":"4.3.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the 2023 National Clinical Key Specialty Major Research Project","award":["Z2023164"],"award-info":[{"award-number":["Z2023164"]}]},{"name":"the China International Medical Foundation","award":["Z-2014-08-2309-1"],"award-info":[{"award-number":["Z-2014-08-2309-1"]}]},{"name":"the Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0506000, 2023ZD0516400 and 2024ZD0529802"],"award-info":[{"award-number":["2023ZD0506000, 2023ZD0516400 and 2024ZD0529802"]}]},{"name":"the National Key Clinical Specialty Construction Projects of China"},{"name":"the Beijing Kangmeng Charity Foundation Health Development Promotion Program - Research Project on Immunotherapy for Chronic Airway Diseases","award":["KM-MXQD-003"],"award-info":[{"award-number":["KM-MXQD-003"]}]},{"name":"the Fundamental Research Funds for the Central Universities of Central South University","award":["No. 2024ZZTS0533"],"award-info":[{"award-number":["No. 2024ZZTS0533"]}]},{"name":"the China Health & Medical Development Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Illness"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Long-term health effects of Omicron infection, particularly persistent Long COVID in hospitalized patients, require further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients hospitalized for Omicron infection (Dec 2022\u2013Mar 2023) underwent follow-ups at 6 months and 1 year post-discharge. Univariate\/multivariate analyses identified mortality predictors, symptom trends, and optimal CRP levels (mg\/L) thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 410 patients, 59 died; mortality predictors included age (OR = 1.070), ICU admission (OR = 15.748), diabetes (OR = 3.363), antibacterial use (OR = 0.283), and lymphocyte count (OR = 0.099). At 6 months, 86.0% reported \u22651 symptom (83.5% at 1 year). Fatigue, cough, and snoring were most common, with symptom counts decreasing significantly over time. Symptomatic patients had longer hospital stays (P\u2009=\u20090.022), lymphopenia (P\u2009=\u20090.036), and elevated CRP levels (P\u2009=\u20090.010). A CRP level \u226515.38\u2005mg\/L was associated with a greater risk of symptom persistence and may serve as a potential predictive marker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hospitalized Omicron survivors experience prolonged symptoms, with ICU admission, age, and diabetes as key mortality risks. Fatigue and snoring may persist despite overall improvement. Elevated CRP and prolonged hospitalization in symptomatic patients underscore the need for long-term monitoring and interventions targeting high-risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17423953251387913","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T18:02:22Z","timestamp":1763402542000},"page":"504-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Long COVID and symptom persistence in post-discharge omicron patients: Insights into C-reactive protein"],"prefix":"10.1177","volume":"21","author":[{"given":"Jiankang","family":"Wu","sequence":"first","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishu","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Meng","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China"},{"name":"Hunan Provincial Key Laboratory of Critical Quality Attribute of Cell Therapy Products, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-6913","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China"},{"name":"Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China"},{"name":"Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_3_2_2_2","article-title":"COVID-19: WHO declares pandemic because of \u201calarming levels\u201d of spread, severity, and inaction","volume":"368","author":"Mahase E","year":"2020","unstructured":"Mahase E. 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