{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:46:23Z","timestamp":1782283583364,"version":"3.54.5"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Illness"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Community-acquired pneumonia (CAP) is a serious infection in patients with cirrhosis. This study aimed to describe clinical features of patients with cirrhosis and CAP, and to determinate whether cirrhosis is consistently associated with poor outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases were systematically searched for full-text articles comparing patients with and without cirrhosis with CAP and evaluating the impact of cirrhosis on clinical profile and outcomes, from inception to February 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totals of 1485 and 114740 patients with cirrhosis and without cirrhosis with CAP were included, respectively. Patients with cirrhosis had different characteristics and more severe disease at admission compared to patients without cirrhosis (hypotension, altered mental status, hyponatremia, hypoalbuminemia were more frequent in patients with cirrhosis).\n                      <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                      was more frequently identified as the causative pathogen of CAP in patients with cirrhosis, and bloodstream infections were also more common. Likewise, risk of intensive care unit admission and mortality was higher in patients with cirrhosis than in patients without cirrhosis (range 11.1%-23.3% versus 8.8%-17.2% and 2.7%-23% compared with 14.4%-34.5%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Patients with cirrhosis and CAP have a poorer prognosis than patients without cirrhosis. Information on the clinical features of CAP in patients with cirrhosis and on risk factors for poor outcomes remains limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17423953261436458","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:42:31Z","timestamp":1775562151000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of liver cirrhosis on the clinical profile and outcomes in community-acquired pneumonia: A systematic review"],"prefix":"10.1177","volume":"22","author":[{"given":"David","family":"Saavedra","sequence":"first","affiliation":[{"name":"Universidad del Norte and Hospital Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Estupi\u00f1an-Boh\u00f3rquez","sequence":"additional","affiliation":[{"name":"Universidad del Norte and Hospital Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Universidad del Norte and Hospital Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-336X","authenticated-orcid":false,"given":"Emiro","family":"Buendia","sequence":"additional","affiliation":[{"name":"University of Cartagena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Alfonso-Arrieta","sequence":"additional","affiliation":[{"name":"Universidad del Norte and Hospital Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Machado-Contreras","sequence":"additional","affiliation":[{"name":"Universidad del Norte and Hospital Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-3947","authenticated-orcid":false,"given":"Diego","family":"Viasus","sequence":"additional","affiliation":[{"name":"Universidad del Norte and Hospital Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Carratal\u00e0","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge \u2013 Bellvitge Biomedical Research Insitute (IDIBELL); University of Barcelona"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.010"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2019.09.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320876"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0934-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.9.1059"},{"key":"e_1_3_3_8_2","article-title":"Outcomes of adult patients hospitalized with community-acquired pneumonia with liver disease or cirrhosis","volume":"4","author":"Karki BJ","year":"2020","unstructured":"Karki BJ, Ponnekanti SK, Salunkhe V, et al. 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