{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:07:31Z","timestamp":1789222051380,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Illness"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aimed to determine the multidimensional impact of pruritus, to define the impact on quality of life and to identify the experiences of patients with the symptom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mixed-methods study with sequential quantitative and qualitative method with 57 patients experiencing pruritus in the hepatology and internal medicine clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A pruritus prevalence of 37.7% was found, with a mean score of 19.4\u2009\u00b1\u20093.4 (0\u201325) and the daily duration was 18\u201323\u2005h\/day (43.9%). The mean total score of the Liver Disease Symptom Index 2.0 was 66.57\u2009\u00b1\u20099.13 (0\u201396). A correlation was found between elevated GGT levels and pruritus. The qualitative content analysis consisted of three main themes: the meaning of pruritus and scratching; impact on quality of life; and ways of coping\/dealing with pruritus symptom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The study shows that quantitative and qualitative results concurred that pruritus impairs patient's quality of life in regards to sleep, social isolation, daily living activities, and eating habits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17423953261452266","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:11:24Z","timestamp":1781082684000},"page":"240-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Restless and endless symptom? Pruritus in patients with liver diseases: A mix method study"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-4035","authenticated-orcid":false,"given":"Nese","family":"Alt\u0131nok Ersoy","sequence":"first","affiliation":[{"name":"Hacettepe University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-8099","authenticated-orcid":false,"given":"Imatullah","family":"Akyar","sequence":"additional","affiliation":[{"name":"Hacettepe University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00687-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12978"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2020.04.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165958"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871523020666210114092924"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82566-w"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-018-0090-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3064"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1610-0387.2012.08028.x","article-title":"Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response","volume":"11","author":"Huesmann M","year":"2013","unstructured":"Huesmann M, Huesmann T, Osada N, et al. 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