{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:32:42Z","timestamp":1777944762841,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pain hypoalgesia has been reported in Rett syndrome patients, a severe neurodevelopmental disorder which can be attributed to mutations in the methyl-CpG binding protein 2 (MeCP2). Here, we examined the role of MeCP2 signaling in tongue heat sensitivity in the normal and inflamed state using Mecp2 heterozygous (Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      ) mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Heat hypoalgesia of the tongue occurred in Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice and submucosal injection of complete Freund\u2019s adjuvant into the tongue produced a long-lasting heat hyperalgesia at the inflamed site in wild-type mice but not in Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice. Transient receptor potential vanilloid 1 was expressed in a large number of MeCP2-immunoreactive trigeminal ganglion neurons innervating the tongue in both wild-type and Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice (70.9% in wild type; 72.1% in Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      ). The number of transient receptor potential vanilloid 1-immunoreactive trigeminal ganglion neurons innervating the tongue was smaller in Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice relative to wild-type mice (30.5% in wild type; 20.2% in Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      ). Following complete Freund\u2019s adjuvant injection, the number of transient receptor potential vanilloid 1- and MeCP2-immunoreactive trigeminal ganglion neurons innervating the tongue, as well as MeCP2 protein expression in trigeminal ganglion, was significantly increased in wild-type mice but not in Mecp2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice. Additionally, tongue heat hyperalgesia following complete Freund\u2019s adjuvant injection was completely suppressed by the administration of SB366791, a transient receptor potential vanilloid 1 antagonist, in the tongue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that tongue heat sensitivity and hypersensitivity are dependent on the expression of transient receptor potential vanilloid 1 which is regulated via MeCP2 signaling in trigeminal ganglion neurons innervating the tongue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1744806916633206","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T21:53:30Z","timestamp":1457474010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice"],"prefix":"10.1177","volume":"12","author":[{"given":"Azumi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"bibr1-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"bibr2-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.001"},{"key":"bibr3-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1139\/O08-115"},{"key":"bibr4-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.07.006"},{"key":"bibr5-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81887-5"},{"key":"bibr6-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.438697"},{"key":"bibr7-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1878"},{"key":"bibr8-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78167"},{"key":"bibr9-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3897"},{"key":"bibr10-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33314"},{"key":"bibr11-1744806916633206","doi-asserted-by":"publisher","DOI":"10.3109\/07367228709144606"},{"key":"bibr12-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.006"},{"key":"bibr13-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514565645"},{"key":"bibr14-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"bibr15-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80564-4"},{"key":"bibr16-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20079"},{"key":"bibr17-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.251751"},{"key":"bibr18-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-007-0013-2"},{"key":"bibr19-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-9-68"},{"key":"bibr20-1744806916633206","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511413284"},{"key":"bibr21-1744806916633206","first-page":"195","volume":"36","author":"Koto 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