{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:53:06Z","timestamp":1791942786842,"version":"4.3.4"},"reference-count":80,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pain is often accompanied by short-term memory deficit and depression. Currently, it is believed that short-term memory deficit and depression are consequences of chronic pain. Here, we test the hypothesis that the symptoms might be caused by overproduction of interleukin-1beta (IL-1\u03b2) in the injured nerve independent of neuropathic pain following spared nerve injury in rats and mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mechanical allodynia, a behavioral sign of neuropathic pain, was not correlated with short-term memory deficit and depressive behavior in spared nerve injury rats. Spared nerve injury upregulated IL-1\u03b2 in the injured sciatic nerve, plasma, and the regions in central nervous system closely associated with pain, memory and emotion, including spinal dorsal horn, hippocampus, prefrontal cortex, nucleus accumbens, and amygdala. Importantly, the spared nerve injury-induced memory deficits, depressive, and pain behaviors were substantially prevented by peri-sciatic administration of IL-1\u03b2 neutralizing antibody in rats or deletion of IL-1 receptor type 1 in mice. Furthermore, the behavioral abnormalities induced by spared nerve injury were mimicked in na\u00efve rats by repetitive intravenous injection of re combinant rat IL-1\u03b2 (rrIL-1\u03b2) at a pathological concentration as determined from spared nerve injury rats. In addition, microglia were activated by both spared nerve injury and intravenous injection of rrIL-1\u03b2 and the effect of spared nerve injury was substantially reversed by peri-sciatic administration of anti-IL-1\u03b2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuropathic pain was not necessary for the development of cognitive and emotional disorders, while the overproduction of IL-1\u03b2 in the injured sciatic nerve following peripheral nerve injury may be a common mechanism underlying the generation of neuropathic pain, memory deficit, and depression.<\/jats:p>\n                  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Medicine, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lin","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuvika","family":"Murugan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 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