{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:33:19Z","timestamp":1777944799793,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistently active PKM\u03b6 has been implicated in maintaining spinal nociceptive sensitization that underlies pain hypersensitivity. However, evidence for PKM\u03b6 in the maintenance of pain hypersensitivity comes exclusively from short-term studies in males using pharmacological agents of questionable selectivity. The present study examines the contribution of PKM\u03b6 to long-lasting allodynia associated with neuropathic, inflammatory, or referred visceral and muscle pain in males and females using pharmacological inhibition or genetic ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pharmacological inhibition or genetic ablation of PKM\u03b6 reduced mild formalin pain and slowly developing contralateral allodynia in nerve-injured rats, but not moderate formalin pain or ipsilateral allodynia in models of neuropathic and inflammatory pain. Pharmacological inhibition or genetic ablation of PKM\u03b6 also effectively reduced referred visceral and muscle pain in male, but not in female mice and rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We show pharmacological inhibition and genetic ablation of PKM\u03b6 consistently attenuate long-lasting pain hypersensitivity. However, differential effects in models of referred versus inflammatory and neuropathic pain, and in males versus females, highlight the roles of afferent input-dependent masking and sex differences in the maintenance of pain hypersensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1744806916675347","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T23:32:12Z","timestamp":1480462332000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Consistent sex-dependent effects of PKM\u03b6 gene ablation and pharmacological inhibition on the maintenance of referred pain"],"prefix":"10.1177","volume":"12","author":[{"given":"Hibatulnaseer","family":"Nasir","sequence":"first","affiliation":[{"name":"Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada"},{"name":"Department of Anesthesia, McGill University, Montreal, QC, 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Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Vaigunda","family":"Ragavendran","sequence":"additional","affiliation":[{"name":"Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada"},{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Laferri\u00e8re","sequence":"additional","affiliation":[{"name":"Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada"},{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Stochaj","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence J","family":"Coderre","sequence":"additional","affiliation":[{"name":"Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada"},{"name":"Department of Anesthesia, McGill University, Montreal, QC, Canada"},{"name":"Division of Experimental Medicine, McGill University, Montreal, Quebec, 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