{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:56:10Z","timestamp":1791615370103,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Peripheral nerve injury-caused hyperexcitability and abnormal ectopic discharges in the primary sensory neurons of dorsal root ganglion (DRG) play a key role in neuropathic pain development and maintenance. The two-pore domain background potassium (K\n                    <jats:sub>2P<\/jats:sub>\n                    ) channels have been identified as key determinants of the resting membrane potential and neuronal excitability. However, whether K\n                    <jats:sub>2P<\/jats:sub>\n                    channels contribute to neuropathic pain is still elusive. We reported here that K\n                    <jats:sub>2P<\/jats:sub>\n                    1.1, the first identified mammalian K\n                    <jats:sub>2P<\/jats:sub>\n                    channel, was highly expressed in mouse DRG and distributed in small-, medium-, and large-sized DRG neurons. Unilateral lumbar (L) 4 spinal nerve ligation led to a significant and time-dependent reduction of K\n                    <jats:sub>2P<\/jats:sub>\n                    1.1 mRNA and protein in the ipsilateral L4 DRG, but not in the contralateral L4 or ipsilateral L3 DRG. Rescuing this reduction through microinjection of adeno-associated virus-DJ expressing full-length K\n                    <jats:sub>2P<\/jats:sub>\n                    1.1 mRNA into the ipsilateral L4 DRG blocked spinal nerve ligation-induced mechanical, thermal, and cold pain hypersensitivities during the development and maintenance periods. This DRG viral microinjection did not affect acute pain and locomotor function. Our findings suggest that K\n                    <jats:sub>2P<\/jats:sub>\n                    1.1 participates in neuropathic pain development and maintenance and may be a potential target in the management of this disorder.\n                  <\/jats:p>","DOI":"10.1177\/1744806917701135","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T06:30:01Z","timestamp":1489559401000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Role of dorsal root ganglion K\n                    <sub>2P<\/sub>\n                    1.1 in peripheral nerve injury-induced neuropathic pain"],"prefix":"10.1177","volume":"13","author":[{"given":"Qingxiang","family":"Mao","sequence":"first","affiliation":[{"name":"Deparment of Anesthesiology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China"},{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"},{"name":"Department of Anesthesiology, Daping Hospital, Institute of Surgery Research, The Third Military Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaogen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Daping Hospital, Institute of Surgery Research, The Third Military Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bekker","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Xiang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"},{"name":"Department of Cell Biology & Molecular Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"},{"name":"Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiande","family":"Yang","sequence":"additional","affiliation":[{"name":"Deparment of Anesthesiology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"bibr1-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.021"},{"key":"bibr2-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1046\/j.1533-2500.2002.02011.x"},{"key":"bibr3-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-009-1724-6"},{"key":"bibr4-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-16"},{"key":"bibr5-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1016\/j.rapm.2004.12.001"},{"key":"bibr6-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-007-0007-8"},{"key":"bibr7-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01090.2006"},{"key":"bibr8-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2454-05.2005"},{"key":"bibr9-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.5.F793"},{"key":"bibr10-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80903-4"},{"key":"bibr11-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4183"},{"key":"bibr12-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2013.08.002"},{"key":"bibr13-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-8"},{"key":"bibr14-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000103"},{"key":"bibr15-1744806917701135","doi-asserted-by":"publisher","DOI":"10.1038\/srep37704"},{"key":"bibr16-1744806917701135","doi-asserted-by":"crossref","unstructured":"Liang L, Zhao JY, Gu X, et\u00a0al. G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury.\n                      Mol Pain.\n                      Epub ahead of print 7 December 2016. 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