{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:07:08Z","timestamp":1792919228343,"version":"4.5.0"},"reference-count":95,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Recent data suggest that corneal somatosensory dysfunction may be the underlying cause of severe dry eye symptoms in the absence of ocular surface pathology seen in a subset of patients diagnosed with \u201cdry eye syndrome.\u201d This subset of patients tends to demonstrate a unique constellation of symptoms that are persistent, more severe, and generally respond poorly to current dry eye therapies targeting inadequate or dysfunctional tears. A growing body of literature suggests that symptoms in these patients may be better characterized as neuropathic ocular pain rather than dry eye. In these patients, dry eye symptoms are often associated with numerous comorbid pain conditions and evidence of central pain processing abnormalities, where eye pain is just one of multiple overlapping peripheral manifestations. In this review, we discuss the concept and potential mechanisms of chronic overlapping pain conditions as well as evidence for considering neuropathic ocular pain as one of these overlapping pain conditions.<\/jats:p>","DOI":"10.1177\/1744806917729306","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T03:26:18Z","timestamp":1502940378000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Evidence that dry eye represents a chronic overlapping pain           condition"],"prefix":"10.1177","volume":"13","author":[{"given":"Alexandra E","family":"Levitt","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Galor","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA"},{"name":"Miami Veterans Administration Medical Center,\r        Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesa R","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative\r        Medicine and Pain Management, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R","family":"Felix","sequence":"additional","affiliation":[{"name":"Miami Veterans Administration Medical Center,\r        Miami, FL, USA"},{"name":"Department of Physical Medicine and\r        Rehabilitation, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine D","family":"Sarantopoulos","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA"},{"name":"Department of Anesthesiology, Perioperative\r        Medicine and Pain Management, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald Y","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative\r        Medicine and Pain Management, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Patin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative\r        Medicine and Pain Management, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Maixner","sequence":"additional","affiliation":[{"name":"Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shad B","family":"Smith","sequence":"additional","affiliation":[{"name":"Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eden R","family":"Martin","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA"},{"name":"John T. Macdonald Foundation Department of\r        Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy C","family":"Levitt","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA"},{"name":"Department of Anesthesiology, Perioperative\r        Medicine and Pain Management, Miller School of Medicine, University of Miami, Miami, FL, USA"},{"name":"John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA"},{"name":"John T. 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