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The aim of this study was to investigate the involvement of neutrophils and IL-18 in a mouse model of muscle pain. The right hind leg muscles of BALB\/c mice were stimulated electrically to induce excessive muscle contraction. The left hind leg muscles were not stimulated. The pressure pain threshold, number of neutrophils, and IL-18 levels were investigated. Furthermore, the effects of the IL-18-binding protein and Brilliant Blue G on pain were investigated. In stimulated muscles, pressure pain thresholds decreased, and neutrophil and IL-18 levels increased compared with that in non-stimulated muscles. The administration of IL-18-binding protein and Brilliant Blue G attenuated hyperalgesia caused by excessive muscle contraction. These results suggest that increased IL-18 secretion from larger numbers of neutrophils elicits mechanical hyperalgesia.<\/jats:p>","DOI":"10.1177\/1744806918757286","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T09:56:22Z","timestamp":1516614982000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Involvement of neutrophils and interleukin-18 in nociception in a mouse model of muscle pain"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-2363","authenticated-orcid":false,"given":"Shinichirou","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, 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