{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:52:28Z","timestamp":1789991548247,"version":"4.0.1"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["B07001"],"award-info":[{"award-number":["B07001"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571067, 81521063"],"award-info":[{"award-number":["81571067, 81521063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Ion channels are very important in the peripheral sensitization in neuropathic pain. Our present study aims to investigate the possible contribution of Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.2 T-type calcium channels in damaged dorsal root ganglion neurons in neuropathic pain. We established a neuropathic pain model of rats with spared nerve injury. In these model rats, it was easy to distinguish damaged dorsal root ganglion neurons (of tibial nerve and common peroneal nerve) from intact dorsal root ganglion neurons (of sural nerves). Our results showed that Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.2 protein expression increased in medium-sized neurons from the damaged dorsal root ganglions but not in the intact ones. With whole cell patch clamp recording technique, it was found that after-depolarizing amplitudes of the damaged medium-sized dorsal root ganglion neurons increased significantly at membrane potentials of \u221285\u2009mV and \u221295\u2009mV. These results indicate a functional up-regulation of Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.2 T-type calcium channels in the damaged medium-sized neurons after spared nerve injury. Behaviorally, blockade of Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.2 with antisense oligodeoxynucleotides could significantly reverse mechanical allodynia. These results suggest that Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.2 T-type calcium channels in damaged medium-sized dorsal root ganglion neurons might contribute to neuropathic pain after peripheral nerve injury.\n                  <\/jats:p>","DOI":"10.1177\/1744806918765808","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:57:57Z","timestamp":1522285077000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Increased expression of Ca\n                    <sub>V<\/sub>\n                    3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury"],"prefix":"10.1177","volume":"14","author":[{"given":"Xue-Jing","family":"Kang","sequence":"first","affiliation":[{"name":"Neuroscience Research Institute, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Nan","family":"Chi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Peking University, Beijing, China"},{"name":"Department of Anesthesiology, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Cui","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Peking University, Beijing, 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