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However, little is known regarding the possible involvement of mGluR5 and TRPV1 in regulating visceral nociception from the uterine cervix. In this study, we used a rat model of uterine cervical distension to examine the effects of noxious stimuli to the uterine cervix on expression of spinal mGluR5 and TRPV1. Our findings included the following: (1) uterine cervical distension resulted in a stimulus-dependent increase in electromyographic, spinal c-Fos signal, and expression of mGluR5 and TRPV1 in the spinal cord; (2) intrathecal administration of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyri-dine significantly reduced the increased TRPV1 and c-Fos expression induced by uterine cervical distension; (3) the TRPV1 inhibitor SB-366791 inhibited increased spinal c-Fos expression but had no effect on the expression of mGluR5 in response to uterine cervical distension. Our findings indicate that the spinal mGluR5-TRPV1 pathway modulates nociceptive transmission in uterine cervical distension-induced pathological visceral pain.<\/jats:p>","DOI":"10.1177\/1744806918816850","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T06:13:52Z","timestamp":1542348832000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Involvement of mGluR5 and TRPV1 in visceral nociception in a rat model of uterine cervical distension"],"prefix":"10.1177","volume":"14","author":[{"given":"Wenxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Drzymalski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 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