{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:25Z","timestamp":1792800025292,"version":"4.5.0"},"reference-count":115,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Fibromyalgia is a disease characterized by chronic widespread pain with additional symptoms, such as joint stiffness, fatigue, sleep disturbance, cognitive dysfunction, and depression. Currently, fibromyalgia diagnosis is based exclusively on a comprehensive clinical assessment, according to 2016 ACR criteria, but validated biological biomarkers associated with fibromyalgia have not yet been identified. Genome-wide association studies investigated genes potentially involved in fibromyalgia pathogenesis highlighting that genetic factors are possibly responsible for up to 50% of the disease susceptibility. Potential candidate genes found associated to fibromyalgia are SLC64A4, TRPV2, MYT1L, and NRXN3. Furthermore, a gene-environmental interaction has been proposed as triggering mechanism, through epigenetic alterations: In particular, fibromyalgia appears to be characterized by a hypomethylated DNA pattern, in genes implicated in stress response, DNA repair, autonomic system response, and subcortical neuronal abnormalities. Differences in the genome-wide expression profile of microRNAs were found among multiple tissues, indicating the involvement of distinct processes in fibromyalgia pathogenesis. Further studies should be dedicated to strength these preliminary findings, in larger multicenter cohorts, to identify reliable directions for biomarker research and clinical practice.<\/jats:p>","DOI":"10.1177\/1744806918819944","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T04:39:30Z","timestamp":1543466370000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":153,"title":["Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-9542","authenticated-orcid":false,"given":"Simona","family":"D\u2019Agnelli","sequence":"first","affiliation":[{"name":"Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C","family":"Gerra","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Zatorri","sequence":"additional","affiliation":[{"name":"Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Boggiani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Baciarello","sequence":"additional","affiliation":[{"name":"Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bignami","sequence":"additional","affiliation":[{"name":"Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"bibr1-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.38905"},{"key":"bibr2-1744806918819944","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3904\/kjim.2015.30.4.531","volume":"30","author":"Choi DH and","year":"2015","journal-title":"Korean J Intern Med"},{"key":"bibr3-1744806918819944","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.196"},{"key":"bibr4-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"bibr5-1744806918819944","first-page":"S102","volume":"31","author":"Prados G","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"bibr6-1744806918819944","first-page":"151","volume":"22","author":"Wolfe F","year":"1995","journal-title":"J Rheumatol"},{"key":"bibr7-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.09.008"},{"key":"bibr8-1744806918819944","first-page":"10","volume":"35","author":"Branco JC.","year":"2010","journal-title":"Acta Reumatol Port"},{"key":"bibr9-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149248"},{"key":"bibr10-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03295-2"},{"key":"bibr11-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.032"},{"key":"bibr12-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.006"},{"key":"bibr13-1744806918819944","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jpain.2018.01.010","volume":"19","author":"O\u2019Brien AT","year":"2018","journal-title":"J Pain"},{"key":"bibr14-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00009-6"},{"key":"bibr15-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03324-9"},{"key":"bibr16-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.38191"},{"key":"bibr17-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.10225"},{"key":"bibr18-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"bibr19-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"bibr20-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"bibr21-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.04.018"},{"key":"bibr22-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.02.004"},{"key":"bibr23-1744806918819944","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.2.179"},{"key":"bibr24-1744806918819944","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.37842","volume":"65","author":"Arnold LM","year":"2013","journal-title":"Arthritis Rheum"},{"key":"bibr25-1744806918819944","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1590\/S0482-50042011000600006","volume":"51","author":"Mergener M","year":"2011","journal-title":"Rev Bras Reumatol"},{"key":"bibr26-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.10103"},{"key":"bibr27-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.01.002"},{"key":"bibr28-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.08.001"},{"key":"bibr29-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.24655"},{"key":"bibr30-1744806918819944","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s002960100130","volume":"21","author":"G\u00fcrsoy S","year":"2001","journal-title":"Rheumatol Int"},{"key":"bibr31-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1678-9"},{"key":"bibr32-1744806918819944","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.pain.2014.02.016","volume":"155","author":"Docampo E","year":"2014","journal-title":"Pain"},{"key":"bibr33-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.33338"},{"key":"bibr34-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05623.x"},{"key":"bibr35-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-08024.1997"},{"key":"bibr36-1744806918819944","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neulet.2009.06.021","volume":"461","author":"Juhasz G","year":"2009","journal-title":"Neurosci Lett"},{"key":"bibr37-1744806918819944","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/MCG.0b013e3181dd1573","volume":"45","author":"Park JM","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"bibr38-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30693"},{"key":"bibr39-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.10.008"},{"key":"bibr40-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1186\/ar2316"},{"key":"bibr41-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.24655"},{"key":"bibr42-1744806918819944","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/rheumatology\/41.4.450","volume":"41","author":"Al-Allaf AW","year":"2002","journal-title":"Rheumatology"},{"key":"bibr43-1744806918819944","first-page":"358","volume":"29","author":"Gur A","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr44-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/140832"},{"key":"bibr45-1744806918819944","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1196\/annals.1410.020","volume":"1148","author":"Klingmann PO","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"bibr46-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1091"},{"key":"bibr47-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20328"},{"key":"bibr48-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/140832"},{"key":"bibr49-1744806918819944","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1530-0277.2010.01157.x","volume":"34","author":"Tikkanen R","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"bibr50-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.20258"},{"key":"bibr51-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-8-27"},{"key":"bibr52-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.08.017"},{"key":"bibr53-1744806918819944","doi-asserted-by":"crossref","first-page":"3865249","DOI":"10.1155\/2017\/3865249","volume":"2017","author":"Hellou R","year":"2017","journal-title":"Pain Res Manag"},{"key":"bibr54-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.06.004"},{"key":"bibr55-1744806918819944","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.nicl.2015.02.022","volume":"7","author":"Kim H","year":"2015","journal-title":"Neuroimage Clin"},{"key":"bibr56-1744806918819944","first-page":"S86","volume":"33","author":"H\u00e4user W","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"bibr57-1744806918819944","first-page":"741746","volume":"2012","author":"Becker S","year":"2012","journal-title":"Pain Res Treat"},{"key":"bibr58-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371105"},{"key":"bibr59-1744806918819944","first-page":"154","volume":"19","author":"McCain GA","year":"1989","journal-title":"J Rheumatol Suppl"},{"key":"bibr60-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.07.004"},{"key":"bibr61-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035677"},{"key":"bibr62-1744806918819944","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nrrheum.2016.25","volume":"12","author":"Vasquez A.","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"bibr63-1744806918819944","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1467-8624.2012.01793.x","volume":"84","author":"Szyf M and","year":"2013","journal-title":"Child Dev"},{"key":"bibr64-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.012"},{"key":"bibr65-1744806918819944","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.890707"},{"key":"bibr66-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.06.008"},{"key":"bibr67-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.01.772"},{"key":"bibr68-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1655"},{"key":"bibr69-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.16.2395"},{"key":"bibr70-1744806918819944","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1038\/ncomms3978","volume":"5","author":"Bell JT","year":"2014","journal-title":"Nat Commun"},{"key":"bibr71-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1696-08.2008"},{"key":"bibr72-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.042"},{"key":"bibr73-1744806918819944","first-page":"795784","volume":"2013","author":"Menzies V","year":"2013","journal-title":"Nurs Res Pract"},{"key":"bibr74-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000932"},{"key":"bibr75-1744806918819944","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/1756-185X.12550","volume":"20","author":"Fatima G","year":"2017","journal-title":"Int J Rheum Dis"},{"key":"bibr76-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"bibr77-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035"},{"key":"bibr78-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1038\/nature07242"},{"key":"bibr79-1744806918819944","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1194\/jlr.R034991","volume":"54","author":"Rayner KJ and","year":"2013","journal-title":"J Lipid Res"},{"key":"bibr80-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.003"},{"key":"bibr81-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"bibr82-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078762"},{"key":"bibr83-1744806918819944","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2340\/165019771993117124","volume":"25","author":"Kosek E","year":"1993","journal-title":"Scand J Rehabil Med"},{"key":"bibr84-1744806918819944","first-page":"728","volume":"18","author":"Burckhardt CS","year":"1991","journal-title":"J Rheumatol"},{"key":"bibr85-1744806918819944","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1080\/09638280601055782","volume":"29","author":"Ericsson A and","year":"2007","journal-title":"Disabil Rehabil"},{"key":"bibr86-1744806918819944","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00296-014-3139-3","volume":"35","author":"Bjersing JL","year":"2015","journal-title":"Rheumatol Int"},{"key":"bibr87-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1181"},{"key":"bibr88-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh023"},{"key":"bibr89-1744806918819944","doi-asserted-by":"crossref","first-page":"e0121903","DOI":"10.1371\/journal.pone.0121903","volume":"10","author":"Cerd\u00e1-Olmedo G","year":"2015","journal-title":"PloS One"},{"key":"bibr90-1744806918819944","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1007\/s12035-016-0235-2","volume":"54","author":"Masotti A","year":"2017","journal-title":"Mol Neurobiol"},{"key":"bibr91-1744806918819944","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1093\/eurheartj\/eht007","volume":"34","author":"de Boer HC","year":"2013","journal-title":"Eur Heart J"},{"key":"bibr92-1744806918819944","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1476-4598-9-232","volume":"9","author":"Chhabra R","year":"2010","journal-title":"Mol Cancer"},{"key":"bibr93-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1517-z"},{"key":"bibr94-1744806918819944","doi-asserted-by":"crossref","unstructured":"Ricketts MD, Han J, Szurgot M, Marmorstein R. Molecular basis for chromatin assembly and modification by multi\u2010protein complexes.\n                      Protein Sci\n                      . Epub ahead of print 23 October 2018. DOI: 10.1002\/pro.3535.","DOI":"10.1002\/pro.3535"},{"key":"bibr95-1744806918819944","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.molcel.2004.11.027","volume":"16","author":"Unal E","year":"2004","journal-title":"Mol Cell"},{"key":"bibr96-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909344107"},{"key":"bibr97-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2007.05.008"},{"key":"bibr98-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199808)20:8<615::AID-BIES4>3.0.CO;2-H"},{"key":"bibr99-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.054346"},{"key":"bibr100-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00235-1"},{"key":"bibr101-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052702999"},{"key":"bibr102-1744806918819944","first-page":"89","volume":"34","author":"Jones KD","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"bibr103-1744806918819944","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1568010043343886","volume":"3","author":"O\u2019Connor K","year":"2004","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"bibr104-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20061"},{"key":"bibr105-1744806918819944","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1128\/CVI.00379-09","volume":"17","author":"Nakamura T","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"bibr106-1744806918819944","doi-asserted-by":"publisher","DOI":"10.2174\/138920111798357438"},{"key":"bibr107-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(84)90043-5"},{"key":"bibr108-1744806918819944","first-page":"19615","volume":"6","author":"Massart R","year":"2016","journal-title":"Nature"},{"key":"bibr109-1744806918819944","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ajmg.b.32150","volume":"162","author":"Tylee DS","year":"2013","journal-title":"Am J Med Genet"},{"key":"bibr110-1744806918819944","unstructured":"Xenon Pharmaceuticals Inc. A phase 2a, randomized, double-blind, placebo-controlled, two-period crossover study to evaluate the safety, tolerability, preliminary efficacy, and systemic exposure of topical XPF-002 in subjects with postherpetic neuralgia, https:\/\/ichgcp.net\/clinical-trials-registry\/NCT01195636"},{"key":"bibr111-1744806918819944","unstructured":"Xenon Pharmaceuticals Inc. Phase 2a, exploratory, double-blind, placebo-controlled two-part study to evaluate the safety, efficacy, tolerability and pharmacokinetics of topically applied XPF-002 (XEN402 8% w\/w Ointment) in patients with primary\/inherited erythromelalgia, http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01486446?term=xen402&rank=2"},{"key":"bibr112-1744806918819944","unstructured":"Biogen. A randomized, double blind, cross-over study to evaluate the safety and efficacy of CNV1014802 in subjects with neuropathic pain from lumbosacral radiculopathy, http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01561027?term=CNV1014802&rank=2"},{"key":"bibr113-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1186\/gm416"},{"key":"bibr114-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.08.040"},{"key":"bibr115-1744806918819944","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-061008-103102"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1744806918819944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1744806918819944","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1744806918819944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:16:56Z","timestamp":1777709816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1744806918819944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,29]]},"references-count":115,"alternative-id":["10.1177\/1744806918819944"],"URL":"https:\/\/doi.org\/10.1177\/1744806918819944","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,29]]},"article-number":"1744806918819944"}}