{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:25:11Z","timestamp":1779927911027,"version":"3.53.1"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    The study reported here investigated the role of the central vascular endothelial growth factor-A (VEGF-A) pathway in the development of trigeminal neuropathic pain following nerve injury. A Sprague-Dawley rat model of trigeminal neuropathic pain was produced using malpositioned dental implants. The left mandibular second molar was extracted under anesthesia and replaced with a miniature dental implant to induce injury to the inferior alveolar nerve. The inferior alveolar nerve injury produced a significant upregulation of astrocytic VEGF-A expression in the medullary dorsal horn. The nerve injury-induced mechanical allodynia was inhibited by an intracisternal infusion of VEGF-A\n                    <jats:sub>164<\/jats:sub>\n                    antibody. Although both VEGF-A Receptor 1 (VEGF-A R1; colocalized with the blood\u2013brain barrier) and VEGF-A Receptor 2 (VEGF-A R2; colocalized with astrocytes) participated in the development of trigeminal neuropathic pain following nerve injury, only the intracisternal infusion of a VEGF-A R1 antibody, and not that of a VEGF-A R2 antibody, inhibited the increased blood\u2013brain barrier permeability produced by nerve injury. Finally, we confirmed the participation of the central VEGF-A pathway in the development of trigeminal neuropathic pain by reducing VEGF-A expression using VEGF-A\n                    <jats:sub>164<\/jats:sub>\n                    siRNA. This suppression of VEGF-A produced significant prolonged anti-allodynic effects. These results suggest that the central VEGF-A pathway plays a key role in the development of trigeminal neuropathic pain following nerve injury through two separate pathways: VEGF-A R1 and VEGF-A R2. Hence, a blockade of the central VEGF-A pathway provides a new therapeutic avenue for the treatment of trigeminal neuropathic pain.\n                  <\/jats:p>","DOI":"10.1177\/1744806919872602","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:39:10Z","timestamp":1565339950000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Central VEGF-A pathway plays a key role in the development of trigeminal neuropathic pain in rats"],"prefix":"10.1177","volume":"15","author":[{"given":"Geun W","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Y","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah R","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin S","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong C","family":"Bae","sequence":"additional","affiliation":[{"name":"Oral Anatomy, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-2371","authenticated-orcid":false,"given":"Dong K","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, 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