{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:09Z","timestamp":1787019309840,"version":"build-2736575974"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12HD043441"],"award-info":[{"award-number":["K12HD043441"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Underlying genetic influences may affect perinatal pain, depression, or both. We investigated the role of 59 single-nucleotide polymorphisms on 20 quantitative traits measured in perinatal women. Moreover, 183 pregnant women (28\u201337 weeks\u2019 gestation) were prospectively genotyped for single-nucleotide polymorphisms with known prior associations with either pain or depression in nonpregnant populations. Prenatal saliva samples were collected. Phenotypic data were gathered during prenatal, labor and delivery, and postpartum (six weeks and three months) periods, capturing labor pain, Edinburgh Postnatal Depression Score, and Brief Pain Inventories. Following quality control, genotypes were used as predictors and phenotypes as dependent variables in multiple linear regression analyses to detect associations. Three statistical models were tested: additive allele effects, deviation from dominant allele effects, and the joint test of both. rs4633 (a synonymous single-nucleotide polymorphism in COMT) associated with \u201cpain right now\u201d scores at six weeks postpartum. Single-nucleotide polymorphisms rs1135349 (a single-nucleotide polymorphism within a small noncoding RNA that has many prior associations for depression) and rs7548151 (intronic in ASTN1) were associated with the maximum pain unpleasantness score experienced during labor (a measure of the emotional valence of labor pain), controlling for the Holm\u2013Bonferroni family-wise error rate. Sensory dimensions of labor pain (i.e., pain intensity) and postpartum depression scores were not associated with genotyped single-nucleotide polymorphisms. Identifying genomic components of these perinatal complex disorders may produce insights into relevant pathways or novel treatment options.<\/jats:p>","DOI":"10.1177\/1744806919882139","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T05:33:41Z","timestamp":1569389621000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic associations of perinatal pain and depression"],"prefix":"10.1177","volume":"15","author":[{"given":"Lora","family":"McClain","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Western Psychiatric Institute and Clinic of UPMC, Pittsburgh, PA, USA"},{"name":"University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsea","family":"LaSorda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Western Psychiatric Institute and Clinic of UPMC, Pittsburgh, PA, USA"},{"name":"University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Magee-Womens Research Institute, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8013-0080","authenticated-orcid":false,"given":"Grace","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Magee-Womens Research Institute, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"bibr1-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002720"},{"key":"bibr2-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7744"},{"key":"bibr3-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460326.02891.fc"},{"key":"bibr4-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01938.x"},{"key":"bibr5-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201742"},{"key":"bibr6-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000678"},{"key":"bibr7-1744806919882139","first-page":"10036","volume":"8","author":"Yao P","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr8-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023658"},{"key":"bibr9-1744806919882139","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000204851.15499.fc"},{"key":"bibr10-1744806919882139","unstructured":"Substance Abuse and Mental Health Services Administration.\n                      2016 National Survey on Drug Use and Health\n                      . 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