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Recent studies demonstrate that there are two major forms of long-term potentiation in cortical areas related to pain: postsynaptic long-term potentiation and presynaptic long-term potentiation. In particular, presynaptic long-term potentiation in the anterior cingulate cortex has been shown to contribute to chronic pain-related anxiety. In this review, we briefly summarized the components and roles of extracellular signal-regulated kinases in neuronal signaling, especially in the presynaptic long-term potentiation of anterior cingulate cortex, and discuss the possible molecular mechanisms and functional implications in pain-related emotional disorders.<\/jats:p>","DOI":"10.1177\/1744806920917245","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:46:46Z","timestamp":1586306806000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Presynaptic long-term potentiation requires extracellular signal-regulated kinases in the anterior cingulate cortex"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-6220","authenticated-orcid":false,"given":"Qi-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Neuron and Disease, Frontier Institutes of Science 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