{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:28:58Z","timestamp":1784719738317,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myofascial pain syndrome (MPS) is an important clinical condition that is characterized by chronic muscle pain and a myofascial trigger point (MTrP) located in a taut band (TB). Previous studies showed that EphrinB1 was involved in the regulation of pathological pain via EphB1 signalling, but whether EphrinB1-EphB1 plays a role in MTrP is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study analysed the levels of p-EphB1\/p-EphB2\/p-EphB3 in biopsies of MTrPs in the trapezius muscle of 11 MPS patients and seven healthy controls using a protein microarray kit. EphrinB1-Fc was injected intramuscularly to detect EphrinB1s\/EphB1s signalling in peripheral sensitization. We applied a blunt strike to the left gastrocnemius muscles (GM) and eccentric exercise for 8\u2009weeks with 4\u2009weeks of recovery to analyse the function of EphrinB1\/EphB1 in the muscle pain model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>P-EphB1, p-EphB2, and p-EphB3 expression was highly increased in human muscles with MTrPs compared to healthy muscle. EphB1 (r\u2009=\u20090.723, n\u2009=\u200911, P\u2009&lt;\u20090.05), EphB2 (r\u2009=\u20090.610, n\u2009=\u200911, P\u2009&lt;\u20090.05), and EphB3 levels (r\u2009=\u20090.670, n\u2009=\u200911, P\u2009&lt;\u20090.05) in the MPS group were significantly correlated with the numerical rating scale (NRS) in the MTrPs. Intramuscular injection of EphrinB1-Fc produces hyperalgesia, which can be partially prevented by pre-treatment with EphB1-Fc. The p-EphB1 contents in MTrPs of MPS animals were significantly higher than that among control animals (P\u2009&lt;\u20090.01). Intramuscular administration of the EphB1 inhibitor EphB1-Fr significantly suppressed mechanical hyperalgesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study showed that the increased expression of p-EphB1\/p-EphB2\/p-EphB3 was related to MTrPs in patients with MPS. This report is the first study to examine the function of EphrinB1-EphB1 signalling in primary muscle afferent neurons in MPS patients and a rat animal model. This pathway may be one of the most important and promising targets for MPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1744806920984079","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T01:31:49Z","timestamp":1609119109000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Peripheral EphrinB1\/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-4169","authenticated-orcid":false,"given":"Feihong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Clinic, Qilu Hospital of Shandong University, Ji\u2019nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-7092","authenticated-orcid":false,"given":"Lianying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Clinic, Qilu Hospital of Shandong University, Ji\u2019nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-7371","authenticated-orcid":false,"given":"Qiya","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Clinic, Qilu Hospital of Shandong University, Ji\u2019nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-493X","authenticated-orcid":false,"given":"Feng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Clinic, Qilu Hospital of Shandong University, Ji\u2019nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,27]]},"reference":[{"key":"bibr1-1744806920984079","first-page":"653","volume":"65","author":"Alvarez DJ","year":"2002","journal-title":"Am Fam Physician"},{"key":"bibr2-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-001-0052-8"},{"key":"bibr3-1744806920984079","volume-title":"Myofascial pain and dysfunction: the trigger point manual","volume":"1","author":"Travell JG","year":"1983"},{"key":"bibr4-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03248-4"},{"key":"bibr5-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnx207"},{"key":"bibr6-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-001-0051-9"},{"key":"bibr7-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00526.x"},{"key":"bibr8-1744806920984079","doi-asserted-by":"crossref","unstructured":"Levesque A, Ploteau S, Michel F, Siproudhis L, Bautrant E, Eggermont J, Rabischong B, Volteau C, Perrouin-Verbe MA, Labat JJ. Botulinum toxin infiltrations versus local anaesthetic infiltrations in pelvic floor myofascial pain: multicentre, randomized, double-blind study.\n                      Ann Phys Rehabil Med\n                      . Epub ahead of print 22 January 2020.","DOI":"10.1016\/j.rehab.2019.12.009"},{"key":"bibr9-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2013.801456"},{"key":"bibr10-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.06.023"},{"key":"bibr11-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.340869"},{"key":"bibr12-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2003.10.006"},{"key":"bibr13-1744806920984079","doi-asserted-by":"crossref","unstructured":"Jin F, Guo Y, Wang Z, Badughaish A, Pan X, Zhang L, Qi F. The pathophysiological nature of sarcomeres in trigger points in patients with myofascial pain syndrome: A preliminary study.\n                      Eur J Pain\n                      2020; 24(10): 1968\u20131978.","DOI":"10.1002\/ejp.1647"},{"key":"bibr14-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnx219"},{"key":"bibr15-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.04.010"},{"key":"bibr16-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.03.004"},{"key":"bibr17-1744806920984079","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S185916"},{"key":"bibr18-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2012-010129"},{"key":"bibr19-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03496-2"},{"key":"bibr20-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2002457"},{"key":"bibr21-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.03.019"},{"key":"bibr22-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.922"},{"key":"bibr23-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04452.x"},{"key":"bibr24-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1080\/15216540600756004"},{"key":"bibr25-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410814200"},{"key":"bibr26-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001855"},{"key":"bibr27-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.015"},{"key":"bibr28-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-004-0069-x"},{"key":"bibr29-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000020620.62318.01"},{"key":"bibr30-1744806920984079","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313356200"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1744806920984079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1744806920984079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1744806920984079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:18:18Z","timestamp":1777709898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1744806920984079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":30,"alternative-id":["10.1177\/1744806920984079"],"URL":"https:\/\/doi.org\/10.1177\/1744806920984079","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1744806920984079"}}