{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:33:12Z","timestamp":1777944792202,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NY State Empire Clinical Research Program"},{"name":"NY State Spinal Cord Injury Research Board"},{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","award":["257760"],"award-info":[{"award-number":["257760"]}],"id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Pain affects most individuals with traumatic spinal cord injury (SCI). Major pain types after SCI are neuropathic or nociceptive, often experienced concurrently. Pain after SCI may be refractory to treatments and negatively affects quality of life. Previously, we analyzed whole blood gene expression in individuals with chronic SCI compared to able-bodied (AB) individuals. Most participants with SCI reported pain (N\u2009=\u200919\/28). Here, we examined gene expression of participants with SCI by pain status. Compared to AB, participants with SCI with pain had 468 differentially expressed (DE) genes; participants without pain had 564 DE genes (FDR\u2009&lt;\u20090.05). Among DE genes distinct to participants with SCI with pain, Gene Ontology Biological Process (GOBP) analysis showed upregulated genes were enriched in categories related to T cell activation or inflammation; downregulated genes were enriched in categories related to protein proteolysis and catabolism. Although most participants with pain reported multiple pain types concurrently, we performed a preliminary comparison of gene expression by worst pain problem type. Compared to AB, participants with SCI who ranked neuropathic (N\u2009=\u20099) as worst had one distinct DE gene (TMEM156); participants who ranked nociceptive (N\u2009=\u200910) as worst had 61 distinct DE genes (FDR\u2009&lt;\u20090.05). In the nociceptive group, the GOBP category with the lowest P-value identified among upregulated genes was \u201cpositive regulation of T cell activation\u201d; among downregulated genes it was \u201creceptor tyrosine kinase binding\u201d. An exploratory comparison of pain groups by principal components analysis also showed that the nociceptive group was enriched in T-cell related genes. A correlation analysis identified genes significantly correlated with pain intensity in the neuropathic or nociceptive groups (N\u2009=\u2009145, 65, respectively, Pearson\u2019s correlation r\u2009&gt;\u20090.8). While this pilot study highlights challenges of identifying gene expression profiles that correlate with specific types of pain in individuals with SCI, it suggests that T-cell signaling should be further investigated in this context.<\/jats:p>","DOI":"10.1177\/17448069211007289","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:55:20Z","timestamp":1618444520000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury"],"prefix":"10.1177","volume":"17","author":[{"given":"Debra","family":"Morrison","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A","family":"Arcese","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janay","family":"Parrish","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Beaufort","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Herman","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam B","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-2392","authenticated-orcid":false,"given":"Ona","family":"Bloom","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA"},{"name":"Department of Molecular Medicine, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"bibr1-17448069211007289","volume-title":"Facts and figures at a glance","author":"National Spinal Cord Injury Statistical Center.","year":"2020"},{"key":"bibr2-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.905"},{"key":"bibr3-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2017.1351051"},{"key":"bibr4-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101777"},{"key":"bibr5-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.157"},{"key":"bibr6-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.10.036"},{"key":"bibr7-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-9651(18)30152-9"},{"key":"bibr8-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2007.11753405"},{"key":"bibr9-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1038\/s41394-019-0178-8"},{"key":"bibr10-17448069211007289","doi-asserted-by":"crossref","unstructured":"Widerstr\u00f6m-Noga E, Biering-S\u00f8rensen F, Bryce TN, Cardenas DD, Finnerup NB, Jensen MP, Richards JS and Siddall PJ.  The International Spinal Cord Injury Pain Basic Data Set (version 2.0).\n                      Spinal Cord\n                      . 2014;  52: 282\u2013286.","DOI":"10.1038\/sc.2014.4"},{"key":"bibr11-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.156"},{"key":"bibr12-17448069211007289","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822060-00002"},{"key":"bibr13-17448069211007289","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.15.47"},{"key":"bibr14-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-018-0171-2"},{"key":"bibr15-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.02.001"},{"key":"bibr16-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.12.003"},{"key":"bibr17-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113143"},{"key":"bibr18-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.009"},{"key":"bibr19-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5819"},{"key":"bibr20-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3386-11.2011"},{"key":"bibr21-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.040"},{"key":"bibr22-17448069211007289","doi-asserted-by":"crossref","unstructured":"Hameed S., Nav1 7. and Nav1.8: role in the pathophysiology of pain.\n                      Mol Pain\n                      2019; 15: 1744806919858801.","DOI":"10.1177\/1744806919858801"},{"key":"bibr23-17448069211007289","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00257"},{"key":"bibr24-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.026"},{"key":"bibr25-17448069211007289","first-page":"1","volume":"2017","author":"Zhang G","year":"2017","journal-title":"Biomed Res Int"},{"key":"bibr26-17448069211007289","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5519"},{"key":"bibr27-17448069211007289","unstructured":"Oliveros JC. 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Inflamm-aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2006;  908: 244\u2013254.","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069211007289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17448069211007289","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069211007289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:18:23Z","timestamp":1777709903000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069211007289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":46,"alternative-id":["10.1177\/17448069211007289"],"URL":"https:\/\/doi.org\/10.1177\/17448069211007289","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"17448069211007289"}}