{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:53:07Z","timestamp":1793123587059,"version":"4.5.0"},"reference-count":52,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"crossref","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scienti\ufb01c Research (KAKENHI) program","award":["18K16633"],"award-info":[{"award-number":["18K16633"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rotator cuff tears (RCTs) are often associated with severe shoulder pain. Non-steroidal anti-inflammatory drugs, not recommended for long-term use, do not effectively manage RCT-induced pain, resulting in reduced quality of life. To improve management, a better understanding of the fundamental properties of RCT pain is needed. Here, we aimed to compare the expression levels of nerve growth factor (NGF) and cyclooxygenase-2 (COX-2) mRNA in the synovial tissues of patients with RCT-induced pain and patients with non-painful recurrent shoulder dislocation (RSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 32 patients with RCT who underwent arthroscopic rotator cuff repair and 28 patients with non-painful RSD who underwent arthroscopic Bankart repair. Synovial tissue samples were harvested from subacromial bursa and rotator interval of RCT patients and from the rotator interval of RSD patients. Samples were analyzed quantitatively expression levels for NGF and COX2 mRNA and NGF protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NGF mRNA and protein levels were significantly higher in the rotator interval of RCT patients than in the rotator interval of RSD patients ( p\u2009=\u20090.0017, p\u2009=\u20090.012, respectively), while COX2 mRNA levels did not differ significantly between the two patient groups. In RCT patients, COX2 mRNA was more highly expressed in the rotator interval than in the subacromial bursa ( p\u2009=\u20090.038), whereas the mRNA and protein levels of NGF did not differ between the two tissues. The expression of NGF mRNA in the synovium of the rotator interval was significantly correlated with the numeric rating scale of pain (\u03c1\u2009=\u20090.38, p\u2009=\u20090.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NGF mRNA and protein levels were elevated in patients with painful RCT compared with those in patients with non-painful RSD, whereas COX-2 levels were comparable in the two patient groups. These findings provide insights into novel potential strategies for clinical management of RCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17448069211021252","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T03:37:47Z","timestamp":1622691467000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased nerve growth factor expression in the synovial tissues of patients with rotator cuff tears"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-7377","authenticated-orcid":false,"given":"Ryo","family":"Tazawa","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-5357","authenticated-orcid":false,"given":"Tomonori","family":"Kenmoku","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Center for Neuroplasticity and Pain, School of Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshige","family":"Nagura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsufumi","family":"Nakawaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenori","family":"Jimbo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinari","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Takaso","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"bibr1-17448069211021252","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B2.21069"},{"key":"bibr2-17448069211021252","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2009.04.006"},{"key":"bibr3-17448069211021252","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01304"},{"key":"bibr4-17448069211021252","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000812"},{"key":"bibr5-17448069211021252","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201501060"},{"key":"bibr6-17448069211021252","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.suppl_1.33"},{"key":"bibr7-17448069211021252","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1742-1241.1998.tb11598.x","volume":"52","author":"Wober W","year":"1998","journal-title":"Int J Clin Pract"},{"key":"bibr8-17448069211021252","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002216"},{"key":"bibr9-17448069211021252","unstructured":"National Institute for Health and Care Excellence (2015) Clinical knowledge summaries. 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