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Praeruptorin C (Pra-C) is a main active ingredient derived from Peucedanum praeruptorum Dunn, traditionally used as antibechic, anti-bronchitis and anti-hypertension drug. Here, we evaluated the effects of Pra-C in a chronic inflammatory pain mouse model induced by complete Freund\u2019s adjuvant (CFA) injection. Pra-C (3 mg\/kg) treatment for just 3 days after CFA challenge relieved CFA-induced mechanical allodynia and hindpaw edema in mice. In the anterior cingulate cortex (ACC), Pra-C treatment inhibited microglia activation and reduced levels of proinflammatory cytokines, TNF-\u03b1 and IL-1\u03b2, and suppressed upregulation of glutamate receptors caused by CFA injection. In addition, Pra-C attenuated neuronal hyperexcitability in ACC of CFA-injected mice. In vitro studies confirmed the analgesic effect of Pra-C was due to its inhibitory ability on microglial activation. In conclusion, Pra-C administration had a certain effect on relieving chronic pain by inhibiting microglial activation, attenuating proinflammatory cytokine releasing and regulating excitatory synaptic proteins in the ACC of the CFA-injected mice.<\/jats:p>","DOI":"10.1177\/1744806921990934","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:12:29Z","timestamp":1613851949000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund\u2019s adjuvant-induced mouse model"],"prefix":"10.1177","volume":"17","author":[{"given":"Dan-jie","family":"Su","sequence":"first","affiliation":[{"name":"First Clinical Medical College of Shanxi Medical University, Taiyuan, 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