{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:34:14Z","timestamp":1777944854530,"version":"3.51.4"},"reference-count":91,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health, USA","doi-asserted-by":"publisher","award":["R01 DE029074"],"award-info":[{"award-number":["R01 DE029074"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971049, 81671097"],"award-info":[{"award-number":["81971049, 81671097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n                    Oxytocin (OT) is recognized as a critical neuropeptide in pain-related disorders. Chronic pain caused by the comorbidity of temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) is common, but whether OT plays an analgesic role in the comorbidity of TMD and FMS is unknown. Female rats with masseter muscle inflammation combined with 3-day forced swim (FS) stress developed somatic hypersensitivity, which modeled the comorbidity of TMD and FMS. Using this model, the effects of spinal OT administration on mechanical allodynia and thermal hyperalgesia in hindpaws were examined. Furthermore, the protein levels of OT receptors and 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptors in the L4\u2013L5 spinal dorsal horn were analyzed by Western blot. The OT receptor antagonist atosiban and 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor antagonist ritanserin were intrathecally injected prior to OT injection in the separate groups. Intrathecal injection of 0.125\u00a0\u03bcg and 0.5\u00a0\u03bcg OT attenuated the hindpaw hyperalgesia. The expression of OT receptors and 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptors in the L4\u2013L5 spinal dorsal horn significantly increased following intrathecal injection of 0.5\u00a0\u03bcg OT. Intrathecal administration of either the OT receptor antagonist atosiban or 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor antagonist ritanserin blocked the analgesic effect of OT. These results suggest that OT may inhibit hindpaw hyperalgesia evoked by orofacial inflammation combined with stress through OT receptors and\/or 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptors, thus providing a therapeutic prospect for drugs targeting the OT system and for patients with comorbidity of TMD and FMS.\n                  <\/jats:p>","DOI":"10.1177\/17448069221089591","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T08:31:35Z","timestamp":1646901095000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress"],"prefix":"10.1177","volume":"18","author":[{"given":"Yue-Xin","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi\u2019an Jiaotong University College of Stomatology, China"},{"name":"Department of Special Dental Care, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Heng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Ying","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Hao","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi\u2019an Jiaotong University College of Stomatology, China"},{"name":"Department of Special Dental Care, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Traub","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences, School of Dentistry, Center to Advance Chronic Pain Research, University of Maryland Baltimore, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-5291","authenticated-orcid":false,"given":"Hong","family":"An","sequence":"additional","affiliation":[{"name":"Department of Special Dental Care, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-2885","authenticated-orcid":false,"given":"Dong-Yuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi\u2019an Jiaotong University College of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"bibr1-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1389296"},{"key":"bibr2-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001390"},{"key":"bibr3-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1080\/09540261.2016.1191448"},{"key":"bibr4-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2019.1650215"},{"key":"bibr5-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516657070"},{"key":"bibr6-17448069221089591","first-page":"190","volume":"25","author":"Plesh O","year":"2011","journal-title":"J Orofacial Pain"},{"key":"bibr7-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1221788"},{"key":"bibr8-17448069221089591","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S109038"},{"key":"bibr9-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0251-z"},{"key":"bibr10-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.01.006"},{"key":"bibr11-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.08.007"},{"key":"bibr12-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.08.010"},{"key":"bibr13-17448069221089591","first-page":"2305","volume":"28","author":"McBeth J","year":"2001","journal-title":"J Rheumatology"},{"key":"bibr14-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00374-9"},{"key":"bibr15-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04224-5"},{"key":"bibr16-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.09.006"},{"key":"bibr17-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-69"},{"key":"bibr18-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.02.007"},{"key":"bibr19-17448069221089591","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2018-0024"},{"key":"bibr20-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.041"},{"key":"bibr21-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.08.015"},{"key":"bibr22-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109411"},{"key":"bibr23-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415618615"},{"key":"bibr24-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.629"},{"key":"bibr25-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277178"},{"key":"bibr26-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00683-0"},{"key":"bibr27-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.003"},{"key":"bibr28-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.03.076"},{"key":"bibr29-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00665"},{"key":"bibr30-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"bibr31-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5593-08.2009"},{"key":"bibr32-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20566"},{"key":"bibr33-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0659-17.2017"},{"key":"bibr34-17448069221089591","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1038\/sj.embor.7401008","volume":"8","author":"Lesch KP","year":"2007","journal-title":"EMBO Reports"},{"key":"bibr35-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09635.2002"},{"key":"bibr36-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-10-03572.2001"},{"key":"bibr37-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00978.x"},{"key":"bibr38-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13833"},{"key":"bibr39-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.06.008"},{"key":"bibr40-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00645-x"},{"key":"bibr41-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307748"},{"key":"bibr42-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.02.022"},{"key":"bibr43-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916660722"},{"key":"bibr44-17448069221089591","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00248"},{"key":"bibr45-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00117.2004"},{"key":"bibr46-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03019-1"},{"key":"bibr47-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-011-1035-3"},{"key":"bibr48-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000930"},{"key":"bibr49-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90296-6"},{"key":"bibr50-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(91)90441-8"},{"key":"bibr51-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"bibr52-17448069221089591","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"},{"key":"bibr53-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2019.101996"},{"key":"bibr54-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.05.044"},{"key":"bibr55-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-007-0023-x"},{"key":"bibr56-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15447"},{"key":"bibr57-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02690-8"},{"key":"bibr58-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12773-7"},{"key":"bibr59-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03346-7"},{"key":"bibr60-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(03)00152-6"},{"key":"bibr61-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.02.011"},{"key":"bibr62-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.12.006"},{"key":"bibr63-17448069221089591","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2285"},{"key":"bibr64-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000808"},{"key":"bibr65-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.03.020"},{"key":"bibr66-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199404150-00001"},{"key":"bibr67-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.5.741"},{"key":"bibr68-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2012.12.003"},{"key":"bibr69-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2018.12.011"},{"key":"bibr70-17448069221089591","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00030"},{"key":"bibr71-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_14"},{"key":"bibr72-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.05.031"},{"key":"bibr73-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880108"},{"key":"bibr74-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.09.041"},{"key":"bibr75-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.11.018"},{"key":"bibr76-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00394.x"},{"key":"bibr77-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301206"},{"key":"bibr78-17448069221089591","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3807"},{"key":"bibr79-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.05.012"},{"key":"bibr80-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04145-8"},{"key":"bibr81-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.05.001"},{"key":"bibr82-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.08.033"},{"key":"bibr83-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90354-6"},{"key":"bibr84-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.01.050"},{"key":"bibr85-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.029"},{"key":"bibr86-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.07.010"},{"key":"bibr87-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.05.002"},{"key":"bibr88-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.3.8119151"},{"key":"bibr89-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(96)00112-X"},{"key":"bibr90-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2193-16.2016"},{"key":"bibr91-17448069221089591","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2011.04.007"}],"updated-by":[{"DOI":"10.1177\/17448069241281005","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000}}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069221089591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17448069221089591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069221089591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:19:01Z","timestamp":1777709941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069221089591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":91,"alternative-id":["10.1177\/17448069221089591"],"URL":"https:\/\/doi.org\/10.1177\/17448069221089591","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,21]]},"article-number":"17448069221089591"}}