{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:49:25Z","timestamp":1792651765069,"version":"4.5.0"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>To observe the effects of Fu\u2019s subcutaneous needling (FSN) and acupuncture treatment on the mitochondrial structure and function of the skeletal muscle tissue of rats with sciatica. Forty Sprague\u2013Dawley rats were divided into control, model, acupuncture, and FSN groups (10 each) according to a random number table. The control group was left untreated. Rats in the FSN group were treated with FSN once every 2\u00a0days for three times, respectively (days 1, 3, 5, and 7), to cooperate with reperfusion approach. The acupuncture group was treated at the same timeline as that of the FSN group. Changes in the mechanical pain threshold, mitochondrial ultrastructure, mitochondrial citrate synthase (CS) activities, mitochondrial respiratory chain complex II, and mitochondrial COX- I protein expression in the skeletal muscle of rats treated with different treatments were compared with those of the model group. The pain thresholds of the rats were remarkably higher after FSN treatment and acupuncture, and the pain threshold of the FSN group was higher than that of the acupuncture group. Compared with the control group, the mitochondria of the model group had a damaged ultrastructure, were arranged in a disorganized manner, accumulated under the basement membrane, and appeared vacuolated with autophagosomes. The state of mitochondria in the FSN group was close to that in the control group and was remarkably better than that in the acupuncture group. The activities of mitochondrial CS and respiratory chain complex II in the skeletal muscle of the treated rats decreased compared with the control group ( p &lt; 0.05), and their levels were better in the FSN group than in the acupuncture group ( p &lt; 0.05). FSN treatment for 1 week considerably improved the pain thresholds and improved the skeletal muscle mitochondrial ultrastructure and mitochondrial function in rats with sciatica.<\/jats:p>","DOI":"10.1177\/17448069221108717","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T03:45:49Z","timestamp":1654573549000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Fu\u2019s subcutaneous needling on mitochondrial structure and function in rats with sciatica"],"prefix":"10.1177","volume":"18","author":[{"given":"Yaping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Integrated traditional Chinese and Western medicine, Weifang Medical College, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Integrated traditional Chinese and Western medicine, Huangdaoren Shengtang clinic, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-6225","authenticated-orcid":false,"given":"Li-Wei","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan"},{"name":"Department of physical Medicine and Rehabilitation, Asia University Hospital, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"bibr1-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2006.6125"},{"key":"bibr2-17448069221108717","unstructured":"Fu ZH. The Foundation of Fu\u2019s Subcutaneous Needling. Beijing: People\u2019s Medical Publishing House, 2016, pp. 116\u2013117."},{"key":"bibr3-17448069221108717","first-page":"111","volume":"39","author":"Jia W","year":"2019","journal-title":"Chin Acupuncture"},{"key":"bibr4-17448069221108717","first-page":"11","volume":"99","author":"Huang H","year":"2020","journal-title":"Medicine"},{"key":"bibr5-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24710"},{"key":"bibr6-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200606010-00014"},{"key":"bibr7-17448069221108717","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-014-0013-2"},{"key":"bibr8-17448069221108717","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S350688"},{"key":"bibr9-17448069221108717","first-page":"83","volume":"21","author":"Wang WF","year":"2012","journal-title":"Chin Ethnic Folk Med"},{"key":"bibr10-17448069221108717","unstructured":"Qin H. Meta-analysis of the clinical efficacy of floating needle therapy in lumbar disc herniation, 11. Liaoning University of Traditional Chinese Medicine, 2017, pp. 22\u201325."},{"key":"bibr11-17448069221108717","unstructured":"Chou WK. Clinical Study of Acupuncture for Sciatica Treatment. Guangzhou University of Traditional Chinese Medicine, 2010, pp. 24\u201327."},{"key":"bibr12-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00767.2006"},{"key":"bibr13-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.13.3.159"},{"key":"bibr14-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199404000-00006"},{"key":"bibr15-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01300.x"},{"key":"bibr16-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"bibr17-17448069221108717","unstructured":"Liu ZJ. Chinese Veterinary Acupuncture and Moxibustion. China Agricultural Press, 2013, pp. 158\u2013161."},{"key":"bibr18-17448069221108717","first-page":"474","volume":"6","author":"Li XD","year":"2015","journal-title":"Trop Biol J"},{"key":"bibr19-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.230185"},{"key":"bibr20-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880040608"},{"key":"bibr21-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00768.2006"},{"key":"bibr22-17448069221108717","first-page":"0","volume":"89","author":"Sheu ML","year":"2021","journal-title":"Pain"},{"key":"bibr23-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/353916"},{"key":"bibr24-17448069221108717","first-page":"82","volume":"15","author":"Langevin H","year":"2001","journal-title":"Faseb J Official Publ Fed Am Societies Exp Biol"},{"key":"bibr25-17448069221108717","unstructured":"Yuan L, Bai Y, Yong H. Conference Proceedings of the 15th Seminar on Regulatory Mechanism of Acupuncture on Body Function and Unique Clinical Experience of Acupuncture and Moxibustion and the 11th Symposium on Acupuncture and Moxibustion 2010.Anatomical Discover of Meridian and Fascia Theory."},{"key":"bibr26-17448069221108717","first-page":"3","volume":"20","author":"Li QY","year":"2011","journal-title":"External Treat J Traditional Chin Med"},{"key":"bibr27-17448069221108717","first-page":"31","volume":"11","author":"Chou JM","year":"2010","journal-title":"J Mod Integrated Traditional Chin West Med"},{"key":"bibr28-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5951327"},{"key":"bibr29-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X92000047"},{"key":"bibr30-17448069221108717","doi-asserted-by":"publisher","DOI":"10.3109\/07853899708999346"},{"key":"bibr31-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.07.066"},{"key":"bibr32-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23408"},{"key":"bibr33-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.034"},{"key":"bibr34-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.11.006"},{"key":"bibr35-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.06.002"},{"key":"bibr36-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.1.101"},{"key":"bibr37-17448069221108717","first-page":"10","volume":"89","author":"Su BD","year":"2013","journal-title":"Postgrad Med J"},{"key":"bibr38-17448069221108717","first-page":"683","volume":"12","author":"Facecchia K","year":"2011","journal-title":"J Toxicol"},{"key":"bibr39-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1007\/s10541-005-0102-7"},{"key":"bibr40-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.035"},{"key":"bibr41-17448069221108717","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111824"},{"key":"bibr42-17448069221108717","first-page":"1","volume":"160","author":"Valko M","year":"2020","journal-title":"Chem Biol"},{"key":"bibr43-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"bibr44-17448069221108717","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60177-1"},{"key":"bibr45-17448069221108717","first-page":"21","author":"Zaib S","year":"2021","journal-title":"Anti-cancer Agents Med Chem"},{"key":"bibr46-17448069221108717","first-page":"70","volume":"79","author":"Lee C","year":"2015","journal-title":"Circ J Official J Jpn Circ Soc"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069221108717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17448069221108717","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069221108717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:19:08Z","timestamp":1777709948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069221108717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":46,"alternative-id":["10.1177\/17448069221108717"],"URL":"https:\/\/doi.org\/10.1177\/17448069221108717","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"article-number":"17448069221108717"}}